寄生虫衍生成分:对宿主毒理学和药理作用的最新综述

Fabio Leal de Rossini
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引用次数: 0

摘要

寄生虫衍生成分对宿主的毒理学和药理作用已受到广泛关注。从寄生虫-宿主长期进化过程中形成的共适应角度,深入了解寄生虫衍生分子对宿主的毒理学和药理学作用,不仅可以从发病机理上加深对寄生虫致病机制的认识,而且可以从治疗的角度获益。从疾病角度看,基于昆虫源性成分转化与应用的研究开发已经并将继续成为寄生虫学研究领域最热门的研究课题之一。本文综述了近年来几种重要的人畜共患寄生虫及其寄生虫在诱导和调节宿主免疫代谢相关疾病中的毒理学和药理学作用,并对寄生虫学未来的研究方向提出了建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parasite-Derived Components: An Updated Review of the Toxicological and Pharmacological Effects on the Host
The toxicological and pharmacological effects of parasite-derived components on the host have received extensive attention. A deep understanding of the toxicological and pharmacological effects of parasite-derived molecules on the host from the perspective of co-adaptation formed during the long-term parasite-host evolution process will not only deepen the understanding of the pathogenic mechanisms of parasites from the perspective of pathogenesis but also benefit from the perspective of treatment. From the perspective of disease, research and development based on the transformation and application of insect-derived components have become and will continue to be one of the most popular research tasks in the field of parasitology research. This article reviews the toxicological and pharmacological effects of several essential zoonotic parasites and their parasites in recent years in inducing and regulating host immune metabolism-related diseases and makes suggestions for the future direction of parasitology research.
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