Preparation and Evaluation of Aceclofenac microsphere containing Natural gum

Aceclofenac is an oxyacetic and non-steroidal anti-inflammatory drug which has a half-life of 4 h. Aceclofenac is used to reduce fever, inflammation of rheumatoid arthritis, traumatic pain etc. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. Development of aceclofenac microsphere is carried out to achieve sustained release of the drug after administration. The objective of this study was to find out the role of natural gum (Guar gum) for the preparation of microspheres. So, the amounts of natural gum were increased in various formulation at a successive rate. Aceclofenac microsphere is microencapsulated with guar gum and sodium alginate by Ionotropic gelation technique. There are various formulations of microspheres are developed. The prepared microspheres were spherical in shape, white in color and free flowing. Formulated microspheres were characterized for particle size, entrapment efficiency and in vitro drug release study. The aceclofenac microsphere showed particle size ranging from 330±10µm to 210±11µm 86.5% drug entrapment efficiency. The in vitro drug release is carried out up to 9 h in pH 6.8 phosphate buffer solution. F5 formulation showed maximum drug release of about 95.40% after 9 hour.