中重度丘疹性脓疱性痤疮全身治疗的回顾性分析

Q4 Medicine
Irina Khismatulina, Еlena Faizullina
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 Purpose: To compare the results of systemic therapy of moderate-to-severe resistant and severe papulopustular pustular acne with isotretinoin at daily doses of 0.5; 0.7 and 1.0 mg/kg body weight.
 Methods: In a retrospective study, data from outpatient records and facial skin corneometry results of 125 individuals (95 acne patients, 30 healthy individuals) were analyzed. Patients with acne received isotretinoin (Sotret)at a daily dose of0.5; 0.7 or 1.0 mg/kg body weight, with a cumulative dose of 120 mg/kg body weight in all patients. The duration of follow-up of patients, according to outpatient records, was 18 months.
 Results: Isotretinoin systemic therapy was effective in patients in all compared groups. The resolution of inflammatory elements was faster (p0.001) in those who received doses of isotretinoin 0.7 and 1.0 mg/kg body weight. After treatment, elevated values of sebumetry, skin relief, pore size, and pigmentation were normalized in all groups. There was a significant difference in the incidence of adverse events depending on the dose of isotretinoin. The number of patients with relapses registered at 18-week follow-up after therapy in Group I was 6 (18.75%); in Group II, 4 (12.5%); in Group III, 1 (3.2%), the differences between the groups being significant (p=0.003).
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引用次数: 0

摘要

背景:全身异维a酸是治疗痤疮的有效方法,但复发率高,需要寻找最佳的每日剂量以延长疾病缓解期。目的:比较异维甲酸每日剂量0.5对中重度耐药和重度丘疹性脓疱性痤疮的全身治疗效果;0.7和1.0 mg/kg体重。 方法:回顾性分析125例患者(痤疮患者95例,健康者30例)的门诊记录和面部皮肤角膜测量结果。痤疮患者接受异维甲酸(Sotret),每日剂量为0.5;0.7或1.0 mg/kg体重,所有患者累积剂量为120 mg/kg体重。根据门诊记录,患者随访时间为18个月。 结果:各组患者异维甲酸全身治疗均有效。在接受异维甲酸0.7和1.0 mg/kg体重组中,炎症因子的消退速度更快(p0.001)。治疗后,各组皮脂测量、皮肤缓解、毛孔大小和色素沉着的升高值均归一化。根据异维甲酸的剂量不同,不良事件的发生率有显著差异。第一组治疗后随访18周复发患者6例(18.75%);第二组4例(12.5%);ⅲ组1(3.2%),组间差异显著(p=0.003)。 结论:系统异维a酸(Sotret)每日0.5剂量治疗中重度耐药和重度丘疹性痤疮;0.7和1.0 mg/kg,累积剂量为120 mg/kg体重,显示出相当的临床疗效。然而,在18个月的随访期间,复发率与药物的日剂量相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RETROSPECTIVE ANALYSIS OF THE RESULTS OF SYSTEMIC THERAPY OF MODERATE TO SEVERE PAPULO-PUSTULAR ACNE
Background: Systemic isotretinoin is an effective treatment for acne, but the significant relapse rate requires a search for optimal daily doses to prolong disease remission. Purpose: To compare the results of systemic therapy of moderate-to-severe resistant and severe papulopustular pustular acne with isotretinoin at daily doses of 0.5; 0.7 and 1.0 mg/kg body weight. Methods: In a retrospective study, data from outpatient records and facial skin corneometry results of 125 individuals (95 acne patients, 30 healthy individuals) were analyzed. Patients with acne received isotretinoin (Sotret)at a daily dose of0.5; 0.7 or 1.0 mg/kg body weight, with a cumulative dose of 120 mg/kg body weight in all patients. The duration of follow-up of patients, according to outpatient records, was 18 months. Results: Isotretinoin systemic therapy was effective in patients in all compared groups. The resolution of inflammatory elements was faster (p0.001) in those who received doses of isotretinoin 0.7 and 1.0 mg/kg body weight. After treatment, elevated values of sebumetry, skin relief, pore size, and pigmentation were normalized in all groups. There was a significant difference in the incidence of adverse events depending on the dose of isotretinoin. The number of patients with relapses registered at 18-week follow-up after therapy in Group I was 6 (18.75%); in Group II, 4 (12.5%); in Group III, 1 (3.2%), the differences between the groups being significant (p=0.003). Conclusion: Therapy of moderate-to-severe resistant and severe papulopustular acne with systemic isotretinoin (Sotret) at daily doses of 0.5; 0.7 and 1.0 mg/kg at a cumulative dose of 120 mg/kg body weight demonstrates comparable clinical efficacy. However, recurrence rates during the 18-month follow-up period correlated with the daily dose of the drug.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
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