阐明 GxxxG 基因在淀粉样蛋白生成中的作用:针对淀粉样蛋白-β介导的注意力缺失症发病机制的新视角

IF 3.8 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Dibakar Sarkar,  and , Anirban Bhunia*, 
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引用次数: 0

摘要

在蛋白质折叠障碍的研究中,寻找能够揭示关键功能属性的新型结构基团是一个主要重点。数十年来对阿尔茨海默病(AD)的研究一直以淀粉样蛋白β(Aβ)通路为中心,这凸显了它在理解该疾病方面的重要意义。A β通路的多样性以及尚未发现的可能的沉默路径,使跨学科科学界对其望而生畏。在注意力缺失症的研究过程中,Aβ一直处于科学探索和讨论的前沿。在这篇综述中,我们简要介绍了一个潜在的结构基序(GxxxG 基序)的作用,它可能会为 Aβ 冲突提供一个新的视角。我们强调,从结构-功能的角度全面了解该结构单元,可能会为设计新型疗法干预注意力缺失症及相关疾病铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Delineating the Role of GxxxG Motif in Amyloidogenesis: A New Perspective in Targeting Amyloid-Beta Mediated AD Pathogenesis

Delineating the Role of GxxxG Motif in Amyloidogenesis: A New Perspective in Targeting Amyloid-Beta Mediated AD Pathogenesis

Delineating the Role of GxxxG Motif in Amyloidogenesis: A New Perspective in Targeting Amyloid-Beta Mediated AD Pathogenesis

The pursuit of a novel structural motif that can shed light on the key functional attributes is a primary focus in the study of protein folding disorders. Decades of research on Alzheimer’s disease (AD) have centered on the Amyloid β (Aβ) pathway, highlighting its significance in understanding the disorder. The diversity in the Aβ pathway and the possible silent tracks which are yet to discover, makes it exceedingly intimidating to the interdisciplinary scientific community. Over the course of AD research, Aβ has consistently been at the forefront of scientific inquiry and discussion. In this review, we epitomize the role of a potential structural motif (GxxxG motif) that may provide a new horizon to the Aβ conflict. We emphasize on how comprehensive understanding of this motif from a structure–function perspective may pave the way for designing novel therapeutics intervention in AD and related diseases.

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来源期刊
ACS Bio & Med Chem Au
ACS Bio & Med Chem Au 药物、生物、化学-
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: ACS Bio & Med Chem Au is a broad scope open access journal which publishes short letters comprehensive articles reviews and perspectives in all aspects of biological and medicinal chemistry. Studies providing fundamental insights or describing novel syntheses as well as clinical or other applications-based work are welcomed.This broad scope includes experimental and theoretical studies on the chemical physical mechanistic and/or structural basis of biological or cell function in all domains of life. It encompasses the fields of chemical biology synthetic biology disease biology cell biology agriculture and food natural products research nucleic acid biology neuroscience structural biology and biophysics.The journal publishes studies that pertain to a broad range of medicinal chemistry including compound design and optimization biological evaluation molecular mechanistic understanding of drug delivery and drug delivery systems imaging agents and pharmacology and translational science of both small and large bioactive molecules. Novel computational cheminformatics and structural studies for the identification (or structure-activity relationship analysis) of bioactive molecules ligands and their targets are also welcome. The journal will consider computational studies applying established computational methods but only in combination with novel and original experimental data (e.g. in cases where new compounds have been designed and tested).Also included in the scope of the journal are articles relating to infectious diseases research on pathogens host-pathogen interactions therapeutics diagnostics vaccines drug-delivery systems and other biomedical technology development pertaining to infectious diseases.
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