猪样品中五氯酚酸钠及其代谢物的同时测定

IF 2.5 4区工程技术 Q3 CHEMISTRY, ANALYTICAL

Separations Pub Date : 2023-10-11 DOI:10.3390/separations10100537

Qi Jia, Miao Cui, Meiling Li, Yuncheng Li, Fanbing Meng, Yanyang Xu, Yongzhong Qian, Xue Yan, Jing Qiu

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引用次数: 1

摘要

五氯酚(PCP)是一种持久性有机污染物，通常以钠盐(PCP- na)的形式存在，已被禁用多年，但仍可在动物性食品中检测到。本研究在改进的QuEChERS前处理方法的基础上，建立了液相色谱-串联质谱(LC-MS/MS)和气相色谱-串联质谱(GC-MS/MS)同时检测猪(猪肉、脂肪、肝脏、心脏、肺和肾脏)样品中PCP-Na及其代谢物四氯儿茶酚(TCC)、五氯酚乙酸酯(pcp -乙酸酯)和五氯苯甲醚(PCA)的方法。验证结果具有良好的灵敏度，定量限为1 μg/kg ~ 2 μg/kg。加标回收率为60.5 ~ 119.9%，重复间(n = 5)的相对标准偏差(RSD)为0.70% ~ 12.06%。

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Simultaneous Determination of Sodium Pentachlorophenolate and Its Metabolites in Swine Samples

Pentachlorophenol (PCP) is a persistent organic pollutant usually present in the form of sodium salts (PCP-Na) that has been banned for many years, but it can still be detected in animal food. The present study established a method of detecting PCP-Na and its metabolites—tetrachlorocatechol (TCC), pentachlorophenol acetate (PCP-acetate), and pentachloroanisole (PCA)—in swine samples (pork, fat, liver, heart, lungs and kidney), simultaneously using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS) based on the modified QuEChERS pre-treatment method. The validation results exhibited a good sensitivity with limits of quantitation (LOQs) of 1 μg/kg–2 μg/kg. The recoveries of spiked samples were in the range of 60.5–119.9%, with a relative standard deviation (RSD) between replicates (n = 5) of between 0.70% and 12.06%.

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来源期刊

Separations Chemistry-Analytical Chemistry

CiteScore

3.00

自引率

15.40%

发文量

342

审稿时长

12 weeks

期刊介绍： Separations (formerly Chromatography, ISSN 2227-9075, CODEN: CHROBV) provides an advanced forum for separation and purification science and technology in all areas of chemical, biological and physical science. It publishes reviews, regular research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, unique features of this journal: Manuscripts regarding research proposals and research ideas will be particularly welcomed. Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Manuscripts concerning summaries and surveys on research cooperation and projects (that are funded by national governments) to give information for a broad field of users. The scope of the journal includes but is not limited to: Theory and methodology (theory of separation methods, sample preparation, instrumental and column developments, new separation methodologies, etc.) Equipment and techniques, novel hyphenated analytical solutions (significantly extended by their combination with spectroscopic methods and in particular, mass spectrometry) Novel analysis approaches and applications to solve analytical challenges which utilize chromatographic separations as a key step in the overall solution Computational modelling of separations for the purpose of fundamental understanding and/or chromatographic optimization