抑制nf -κb通路减轻肺损伤的保护机制

IF 0.8 4区医学 Q4 BIOPHYSICS

Journal of Mechanics in Medicine and Biology Pub Date : 2023-10-11 DOI:10.1142/s0219519423400870

Na Liu, Wei-Xing Ma, Jing Qi, Yan-Xia Wang, Gui-Fang Ren, Pei Yu, Yu-Han Xie, Lin Xiao, Zong-Run Li

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引用次数: 0

摘要

本文对近10年来发表的74种不同干预方法通过抑制核因子κ B (NF-[公式:见文]B)信号通路对肺损伤的保护机制进行综述。总结NF-[公式:见文]B、MAPK/NF-[公式:见文]B、PI3K/Akt/NF-[公式:见文]B、TLR4/NF-[公式:见文]B、NF-[公式:见文]B/NALP3、NF-[公式:见文]B/NLRP3等NF-[公式:见文]B相关信号通路的实验研究。肺损伤导致世界范围内的高死亡率。许多治疗和预防肺损伤的潜在机制尚不清楚。除了使用肺保护策略外，目前还没有有效的肺损伤治疗药物。先发制人的NF- B抑制可以保护细胞免受损伤，但在分解阶段的抑制会延迟组织修复。因此，我们认为有必要进行进一步的研究，为未来肺损伤的治疗和预防提供更多的见解。

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PROTECTIVE MECHANISM OF ALLEVIATING LUNG INJURY BY INHIBITING NF-κB PATHWAY

This review is to summarize the reports published in the past 10 years on the protective mechanism of 74 different intervention methods on lung injury through restraining nuclear factor kappa-B (NF-[Formula: see text]B) signaling pathway. We summarized the experimental studies on animal lung injury models of NF-[Formula: see text]B, MAPK/NF-[Formula: see text]B, PI3K/Akt/NF-[Formula: see text]B, TLR4/NF-[Formula: see text]B, NF-[Formula: see text]B/NALP3, NF-[Formula: see text]B/NLRP3 and other NF-[Formula: see text]B-related signal pathways. Lung injury leads to high mortality worldwide. Many potential mechanisms for the treatment and prevention of lung injury are still unclear. In addition to the use of lung protection strategies, currently, there are no effective drugs for lung injury treatment. Preemptive NF-[Formula: see text]B inhibition protects cells from damage, but inhibition at the decomposition stage delays tissue repair. Therefore, we think there is a need to conduct further studies that can provide more insights for future treatment and prevention of lung injury.

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来源期刊

Journal of Mechanics in Medicine and Biology 工程技术-工程：生物医学

CiteScore

1.20

自引率

12.50%

发文量

144

审稿时长

2.3 months

期刊介绍： This journal has as its objective the publication and dissemination of original research (even for "revolutionary concepts that contrast with existing theories" & "hypothesis") in all fields of engineering-mechanics that includes mechanisms, processes, bio-sensors and bio-devices in medicine, biology and healthcare. The journal publishes original papers in English which contribute to an understanding of biomedical engineering and science at a nano- to macro-scale or an improvement of the methods and techniques of medical, biological and clinical treatment by the application of advanced high technology. Journal''s Research Scopes/Topics Covered (but not limited to): Artificial Organs, Biomechanics of Organs. Biofluid Mechanics, Biorheology, Blood Flow Measurement Techniques, Microcirculation, Hemodynamics. Bioheat Transfer and Mass Transport, Nano Heat Transfer. Biomaterials. Biomechanics & Modeling of Cell and Molecular. Biomedical Instrumentation and BioSensors that implicate ''human mechanics'' in details. Biomedical Signal Processing Techniques that implicate ''human mechanics'' in details. Bio-Microelectromechanical Systems, Microfluidics. Bio-Nanotechnology and Clinical Application. Bird and Insect Aerodynamics. Cardiovascular/Cardiac mechanics. Cardiovascular Systems Physiology/Engineering. Cellular and Tissue Mechanics/Engineering. Computational Biomechanics/Physiological Modelling, Systems Physiology. Clinical Biomechanics. Hearing Mechanics. Human Movement and Animal Locomotion. Implant Design and Mechanics. Mathematical modeling. Mechanobiology of Diseases. Mechanics of Medical Robotics. Muscle/Neuromuscular/Musculoskeletal Mechanics and Engineering. Neural- & Neuro-Behavioral Engineering. Orthopedic Biomechanics. Reproductive and Urogynecological Mechanics. Respiratory System Engineering...