配方,提高环糊精配合片溶出度的评价

Gowtham Mandadapu, Prachertha Kolli, Venkata Gopaiah Kurra
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引用次数: 0

摘要

片剂由于易于自行给药、体积小、生产简单,是目前使用最广泛的剂型。在许多情况下,快速行动比常规治疗更有必要。为了解决这些缺点,立即释放剂型已成为传统口服剂型的替代品。立即给药后,立即药物释放剂型溶解更快。超级崩解剂如羧甲基纤维素(crosscarmellose)、乙醇酸淀粉钠(Primogel, Explotab)、交联聚乙烯吡罗烷酮(Polyplasdone)等被用作片剂生产的基本方法。这些强力的崩解剂被放入胃部后,会立即溶解药片。在这一领域,肠外剂型和速释液体剂型都已被引入治疗患者。可以使用常见的分散剂如羟丙基甲基纤维素、AOT(二辛基磺基琥珀酸酯)等,以液体剂量形式施用悬浮液。由于立即释放疗法的出现,许多药物,包括神经抑制剂、心血管药物、镇痛药、抗组胺药和其他药物,都可以被认为是这种剂量形式的候选者。由于药品实体的专利寿命即将到期,制药公司经常以新的和改进的剂型创造某种药物实体。在为其患者群体提供更实用的剂型或给药时间表的同时,新剂型使生产商能够扩大市场专有权。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulation & evaluation of cyclodextrin complexed tablets by enhancing the dissolution rate
Tablets are currently the most widely used dosage form due to their ease of self-administration, compactness, and simple production. In many situations, rapid action is necessary rather than conventional therapy. Immediate release dosage forms have become an alternative to traditional oral dose forms in order to address these shortcomings. Immediately after administration, immediate medication release dose forms dissolve more quickly. Super disintegrants such carboxymethylcellulose (Croscarmellose), sodium starch glycolate (Primogel, Explotab), cross-linked polyvinylpyrrolidone (Polyplasdone), and others are employed as the fundamental method in the manufacture of tablets. After being administered to the stomach, these powerful disintegrants instantly dissolve tablets. In this area, parenteral dosage forms and instant release liquid dosage forms have both been introduced for the treatment of patients. It is possible to administer suspensions in liquid dose form using common dispersion agents as hydroxypropyl methylcellulose, AOT (dioctyl sulfosuccinate), etc. Many medications, including neuroleptics, cardiovascular medications, analgesics, antihistamines, and other medications, can be thought of as candidates for this dose form as a result of the advent of immediate release therapy. Pharmaceutical companies frequently create a certain medication entity in a new and improved dosage form as the drug entity's patent life is about to expire. While providing its patient group with a more practical dosage form or dosing schedule, a new dosage form enables a producer to extend market exclusivity.
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