协会和& lt; i> GPX1基因多态性与慢性粉尘性支气管炎的风险

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Byulleten Sibirskoy Meditsiny Pub Date : 2023-10-17 DOI:10.20538/1682-0363-2023-3-36-42

A. G. Zhukova, A. S. Kazitskaya, T. K. Yadykina, O. N. Gulyaeva

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For the first time, we established a statistically significant association between the polymorphisms of the MnSOD (rs4880) and GPX1 genes (rs1050450) and CDB. Thus, the chance of detecting the homozygous A/A (Val/Val) MnSOD genotype in miners with CDB was 2 times higher than in the comparison group ( χ 2 – 5.42; р = 0.02; odds ratio (OR) 2.21; 95% confidence interval (CI) 1.13–4.33), while the chance of detecting the homozygous G/G (Pro/Pro) GPX1 genotype in miners with CDB was almost 6 times higher than in the comparison group (χ2 – 21.47; р = 0.001; OR 5.89; 95% CI 2.65–13.08). It was found that the combination of AA/GG genotypes of the MnSOD / GPX1 genes was significantly associated with a 1.5-fold risk of developing CDB (χ 2 – 11.49; р ˂ 0.001; relative risk (RR) 1.59; 95% CI 1.36–1.84), while the chance of detecting this combination of genotypes in miners with bronchopulmonary pathology was 15 times higher than in the comparison group (OR 15.09; 95% CI 1.99–114.64). Conclusion. 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引用次数: 0

摘要

的目标。评估煤矿工人MnSOD (rs4880)和GPX1 (rs1050450)基因多态性与慢性粉尘性支气管炎发病风险的关系。材料和方法。该研究包括182名长期暴露于高浓度煤尘的煤矿工人，其中116人先前诊断为慢性粉尘性支气管炎(CDB)， 66人没有支气管肺系统病变，在相同的卫生和卫生条件下工作。采用聚合酶链反应研究了MnSOD (rs4880)和GPX1 (rs1050450)基因的多态性。结果。我们首次建立了MnSOD (rs4880)和GPX1基因(rs1050450)多态性与CDB之间的统计学显著相关性。因此，CDB矿工检测纯合A/A (Val/Val) MnSOD基因型的机会比对照组高2倍(χ 2 - 5.42;r = 0.02;优势比(OR) 2.21;95%可信区间(CI) 1.13 ~ 4.33)，而CDB矿工纯合子G/G (Pro/Pro) GPX1基因型检出率几乎是对照组的6倍(χ2 ~ 21.47;r = 0.001;或5.89;95% ci 2.65-13.08)。结果发现，MnSOD / GPX1基因AA/GG基因型组合与发生CDB的1.5倍风险显著相关(χ 2 ~ 11.49;十四日:0.001;相对危险度(RR) 1.59;95% CI 1.36-1.84)，而在有支气管肺病理的矿工中检测到这种基因型组合的机会是对照组的15倍(OR 15.09;95% ci 1.99-114.64)。结论。在rs4880 MnSOD位点携带纯合基因型A/A和在rs1050450 GPX1位点携带G/G被证明是CDB发生的遗传易感性的标志。研究的AA/GG MnSOD / GPX1基因纯合子基因型组合表明发生CDB的风险为1.5倍。携带MnSOD和GPX1基因型(GG/AA、AA/AA和AG/AA)三种组合中的一种，表明对CDB的发展具有抗性。

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Association of MnSOD and GPX1 gene polymorphisms with a risk of chronic dust-induced bronchitis

Aim. To assess the association of the MnSOD (rs4880) and GPX1 (rs1050450) gene polymorphisms with a risk of developing chronic dust-induced bronchitis in workers of the coal mining industry. Materials and methods. The study included 182 coal miners with prolonged exposure to high concentrations of coal dust, including 116 people with a previously established diagnosis of chronic dust-induced bronchitis (CDB) and 66 people without pathology of the bronchopulmonary system, working under the same sanitary and hygienic conditions. Polymorphisms of the MnSOD (rs4880) and GPX1 (rs1050450) genes were studied using polymerase chain reaction. Results. For the first time, we established a statistically significant association between the polymorphisms of the MnSOD (rs4880) and GPX1 genes (rs1050450) and CDB. Thus, the chance of detecting the homozygous A/A (Val/Val) MnSOD genotype in miners with CDB was 2 times higher than in the comparison group ( χ 2 – 5.42; р = 0.02; odds ratio (OR) 2.21; 95% confidence interval (CI) 1.13–4.33), while the chance of detecting the homozygous G/G (Pro/Pro) GPX1 genotype in miners with CDB was almost 6 times higher than in the comparison group (χ2 – 21.47; р = 0.001; OR 5.89; 95% CI 2.65–13.08). It was found that the combination of AA/GG genotypes of the MnSOD / GPX1 genes was significantly associated with a 1.5-fold risk of developing CDB (χ 2 – 11.49; р ˂ 0.001; relative risk (RR) 1.59; 95% CI 1.36–1.84), while the chance of detecting this combination of genotypes in miners with bronchopulmonary pathology was 15 times higher than in the comparison group (OR 15.09; 95% CI 1.99–114.64). Conclusion. Carriage of homozygous genotypes A/A at the rs4880 MnSOD locus and G/G at the rs1050450 GPX1 locus was shown to be a marker of genetic predisposition to the development of CDB. The combination of homozygous genotypes of the studied AA/GG MnSOD / GPX1 genes indicated a 1.5-fold risk of developing CDB. Carrying one of the three combinations of the MnSOD and GPX1 genotypes (GG/AA, AA/AA, and AG/AA) indicated resistance to the development of CDB.

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