比色法和电化学(易触式GCU计)测定痛风和高尿酸血症患者血尿酸的临床应用比较(数据来自一项初步研究)

M. S. Eliseev, E. V. Panina, O. V. Zheliabina
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引用次数: 0

摘要

高尿酸血症(HU)是由血清尿酸(UA)水平高于360 μmol/l引起的一种疾病。HU通常无症状,但在遗传和环境因素的影响下,可发生外周性关节炎(痛风)发作。痛风的缓解是通过UA血清水平的正常化来实现的,这可以通过比色法或电化学方法来确定,尽管后者目前在临床实践中不常用来控制UA水平。目的:比较标准比色法和电化学法(易触式GCU计)监测UA水平的优劣。材料和方法。30例痛风患者被纳入研究。该组包括患有当前/记忆性无症状HU和确诊为痛风(ACR/EULAR 2015标准)的患者。检查包括一般检查、病史记录和实验室检查。比色法测定静脉血血清中UA水平不迟于采集后5分钟,电化学法测定指尖新鲜全毛细血管血中UA水平(易触式GCU仪)-采集后立即测定。结果和讨论。两种比较方法测定的UA血药浓度平均值相差13.9 μmol/l(比色法相差3.9%)。相关系数的高值(r = 0.86)表明比较结果之间线性关系密切,一致性好。该方法也适用于达到正常尿酸血症的患者。结论。电化学测定胡、痛风患者尿酸水平的方法可用于临床实际自我监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of colorimetric and electrochemical (Easy Touch GCU Meter) methods for determination of blood uric acid in clinical practice in patients with gout and hyperuricemia (data from a pilot study)
Hyperuricemia (HU) is a condition caused by an increase in serum uric acid (UA) levels above 360 μmol/l. Often HU is asymptomatic, but under the influence of genetic and environmental factors, attacks of peripheral arthritis (gout) may occur. Remission of gout is achieved by normalization of UA serum levels, which can be determined by a colorimetric or electrochemical method, although the latter is not currently commonly used in clinical practice to control UA levels. Objective: to compare the standard colorimetric and electrochemical methods (Easy Touch GCU Meter) for monitoring UA levels. Material and methods. 30 gout patients were included in the study. This group included subjects with current/anamnestic asymptomatic HU andpatients with a confirmed diagnosis of gout (ACR/EULAR 2015 criteria). The examination included a general examination, history taking, and laboratory testing. The determination of UA level by the colorimetric method in venous blood serum was performed no later than 5 minutes after collection, and the determination of UA level in fresh whole capillary blood from the fingertip by the electrochemical method (Easy Touch GCU Meter) – immediately after collection. Results and discussion. The average values of UA blood level determined by the two compared methods differed by 13.9 μmol/l (3.9 % with respect to the colorimetric method). The high value of the correlation coefficient (r = 0.86) indicates a close linear relationship between the compared results and their good agreement. The method is also applicable in patients with achieved normouricemia. Conclusions. The method of electrochemical determination of UA level in subjects with HU and gout can be used in real clinical practice for self-monitoring.
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