类风湿性关节炎患者外周血单个核细胞NLRP3的表达

Q3 Pharmacology, Toxicology and Pharmaceutics

Fabad Journal of Pharmaceutical Sciences Pub Date : 2023-09-11 DOI:10.55262/fabadeczacilik.1346586

Sezen YILMAZ SARIALTIN, Orhan KÜÇÜKŞAHİN, Cemil NURAL, Leyla Didem KOZACI, Pınar KAYGIN, Gülçin GÜLER ŞİMŞEK, Serpil OĞUZTÜZÜN, Tülay ÇOBAN

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引用次数: 0

摘要

类风湿性关节炎(RA)是一种系统性自身免疫性疾病，主要表现为关节疼痛、肿胀和炎症。个体、遗传和环境因素影响疾病的发展，不仅会累及关节，还会累及其他关节外组织。然而，其发病机制尚未完全阐明。NLRP3是先天免疫系统的关键组成部分，可能参与复发性和慢性炎症，导致炎症相关疾病。因此，在本研究中，我们旨在利用免疫细胞化学方法研究NLRP3在RA患者外周血单个核细胞中的表达谱。我们的研究结果表明，与健康对照组相比，RA患者NLRP3的表达显著增加(p

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NLRP3 expression in peripheral blood mononuclear cells of patients with rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disease mainly characterized by painful, swollen, and inflamed joints. Individual, genetic, and environmental factors influence the development of the disease, which causes involvement not only in the joints but also in other extra-articular tissues. However, its etiopathogenesis has not been fully elucidated yet. NLRP3, which is a key component of innate immune system, may contribute to recurrent and chronic inflammation, resulting in inflammation-related diseases. Therefore, we aimed to investigate the expression profile of NLRP3 in peripheral blood mononuclear cells isolated from patients with RA using immunocytochemical approaches in this study. Our findings demonstrated that NLRP3 expression was significantly increased in patients with RA in comparison with the healthy controls (p

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来源期刊

Fabad Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The FABAD Journal of Pharmaceutical Sciences is published triannually by the Society of Pharmaceutical Sciences of Ankara (FABAD). All expressions of opinion and statements of supposed facts appearing in articles and/or advertisiments carried in this journal are published on the responsibility of the author and/or advertiser, anda re not to be regarded those of the Society of Pharmaceutical Sciences of Ankara. The manuscript submitted to the Journal has the requirement of not being published previously and has not been submitted elsewhere. Manuscripts should be prepared in accordance with the requirements specified as given in detail in the section of “Information for Authors”. The submission of the manuscript to the Journal is not a condition for acceptance; articles are accepted or rejected on merit alone. All rights reserved.