快速溶解片剂(FMTs):革命性的快速缓解-快速溶解技术的深入回顾

None Samira Bano, None Sanket Kumar, None Peeyush Sharma, None Mohamad Taleuzzaman
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引用次数: 0

摘要

速溶片(FMTs)已成为解决与传统口服剂型相关的许多问题的有希望的替代方案。这些药片可以在口腔中迅速溶解并分解,对于那些吞咽传统固体剂型有困难的人来说,这是一种实用且对病人友好的选择。本综述研究全面考察了速溶片在制药行业的各种用途,以及配方策略、生产工艺和制造方法。这些片剂的生产方法多种多样,每种方法都有自己的优点和困难,包括直接压缩、冷冻干燥、升华和喷雾干燥等。本文还讨论了赋形剂、崩解剂、超级崩解剂、常规和专利技术对FMT性能的影响。速溶片剂已被用于各种治疗领域,包括儿科、老年病学和神经病学,在这些领域,依从性和快速开始行动是必不可少的。这是除了他们的病人友好的好处。此外,它们在靶向药物输送和个性化治疗中的用途也有所增加,因为它们具有更高的生物利用度、更低的给药频率和更好的患者依从性。这篇综述提供了对速溶片改进的当前和彻底的检查,包括对其生产程序、配方方法和对制药部门的影响所做的改变。本文的总体目标是为研究人员、配方师和制药行业专家提供有用的资源,这些专家对快速融化片剂的创造和使用感兴趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fast-Melt Tablets (FMTs): Revolutionizing rapid relief-an in-depth review of swift dissolve technology
Fast Melt tablets (FMTs) have become a promising alternative to solve a number of issues related to conventional oral dose forms. These tablets are made to quickly dissolve in the mouth and disintegrate, making them a practical and patient-friendly alternative for people who have trouble swallowing conventional solid dosage forms. This review study thoroughly examines the various uses of fast-melt tablets in the pharmaceutical business, as well as formulation strategies, production processes, and manufacturing methods. These tablets have been produced using a variety of methods, each with their own advantages and difficulties, including direct compression, freeze-drying, sublimation, and spray-drying etc. The review also talks about how excipients, disintegration agents, super disintegrants, and conventional and patented technology affect FMT performance. Fast melt tablets have found use in a variety of therapeutic fields, including pediatrics, geriatrics, and neurology, where compliance and a quick beginning of action are essential. This is in addition to their patient-friendly benefits. Additionally, their usefulness in targeted drug delivery and personalized therapy has increased because of the possibility of higher bioavailability, decreased dose frequency, and improved patient adherence. This review offers a current and thorough examination of the improvements made to fast melt tablets, covering the changes made to their production procedures, formulation methods, and effects on the pharmaceutical sector. This paper's overall goal is to be a useful resource for researchers, formulators, and pharmaceutical industry experts interested in the creation and use of fast melt tablets.
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