微波辅助合成杂环化合物及其抗癌活性

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY
Sasadhar Majhi, Pankaj Kumar Mondal
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引用次数: 0

摘要

摘要:微波辐射是一种最有效的非常规加热方法。在有机合成中,微波辐射已成为一种流行的加热技术,因为它可以提高产品的产量和纯度,将反应时间从几小时缩短到几分钟,并减少不必要的副反应。微波辅助有机合成利用介质体积加热作为一种替代的活化方法,由于热分布均匀,导致快速和更具选择性的转化。杂环化合物在农药、杀菌剂、除草剂等方面的应用在药物的发现和开发过程中具有深远的作用,使其成为最普遍的生物相关分子形式。因此,人们已经做出了巨大的努力,以繁荣绿色路线,在微波辐射下高产合成它们作为一种可持续的工具。在不同的临床应用中,杂环类化合物作为抗癌药物受到了广泛的关注。杂环基团一直是抗癌药物开发的核心部分,包括市场销售的药物,如5-氟尿嘧啶、阿霉素、甲氨蝶呤、柔红霉素等,以及天然生物碱,如长春花碱、长春新碱。本文主要综述了微波辅助合成杂环化合物的研究进展及特定杂环化合物的抗癌活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microwave-assisted Synthesis of Heterocycles and their Anti-cancer Activities
Abstract: One of the most efficient non-conventional heating methods is microwave irradiation. In organic synthesis, microwave irradiation has become a popular heating technique as it enhances product yields and purities, reduces reaction time from hours to minutes, and decreases unwanted side reactions. Microwave-assisted organic synthesis utilizes dielectric volumetric heating as an alternative activation method, which results in rapid and more selective transformations because of the uniform heat distribution. Heterocyclic compounds have a profound role in the drug discovery and development process along with their applications as agrochemicals, fungicides, herbicides, etc., making them the most prevalent form of biologically relevant molecules. Hence, enormous efforts have been made to flourish green routes for their high-yielding synthesis under microwave irradiation as a sustainable tool. Among the different clinical applications, heterocyclic compounds have received considerable attention as anti-cancer agents. Heterocyclic moieties have always been core parts of the development of anti-cancer drugs, including market-selling drugs, i.e., 5-fluorouracil, doxorubicin, methotrexate, daunorubicin, etc., and natural alkaloids, such as vinblastine and vincristine. In this review, we focus on the developments in the microwave-assisted synthesis of heterocycles and the anti-cancer activities of particular heterocycles.
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来源期刊
Current Microwave Chemistry
Current Microwave Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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