过敏原特异性免疫治疗对狗过敏原过敏的变应性鼻炎和/或支气管哮喘患者的疗效第一年的观测数据

M. A. Lykova, S.V. Zaikov
{"title":"过敏原特异性免疫治疗对狗过敏原过敏的变应性鼻炎和/或支气管哮喘患者的疗效第一年的观测数据","authors":"M. A. Lykova, S.V. Zaikov","doi":"10.31655/2307-3373-2023-3-42-48","DOIUrl":null,"url":null,"abstract":"Abstract. Allergen-specific immunotherapy (ASIT) is the only available treatment method aimed at the pathophysiology of allergic diseases, which can modify the course of the disease. However, in the case of hypersensitivity to dog allergens, data on the effectiveness of ASIT are contradictory. The aim of the study: to study the effectiveness of ASIT in patients with allergic rhinitis (AR) and/or bronchial asthma (BA) and hypersensitivity to dog allergens. Materials and methods. The level of specific IgG4 (sIgG4) to dog extract allergens was determined before and one year after the start of treatment, and the results of a questionnaire on symptom control were analyzed in 15 patients with RA, 3 patients with BA, and 5 patients with a combination of RA with BA The results. After 1 year of treatment with ASIT with a dog dander allergen, 9 out of 15 (60 %) patients with AR reported the absence of symptoms. In addition, these individuals had an increase in the level of sIgG4 to the extract of the corresponding allergen. Only 4 (26.6 %) patients with AR noted the onset of rhinitis symptoms only during long-term contact with dogs and controlled these symptoms with the help of antihistamines. In 2 patients, positive dynamics of symptoms were not observed and the level of sIgG did not change relative to the initial level. In all patients with BA, symptoms were well controlled against the background of basic therapy, and a slight increase in sIgG4-antibodies was registered in all examined patients. Among 5 people with a combination of AR and BA, 3 (60 %) patients noted the absence of rhinitis symptoms and good control of BA with the help of basic therapy, and in 2 (40 %) of the examined, the severity of symptoms of both rhinitis and asthma did not change significantly after undergoing therapy. The average increase in the level of sIgG4 was 2.5 mg/l. The majority of patients with positive test results for sIgG4 were monosensitized to the main component of canine lipocalin Can f1 (8 of 15 patients). As for the patients in whom ASIT was insufficiently effective, all of them (4 persons) were sensitized to both the main dog allergens Can f1 and Can f5. Conclusions. ASIT with dog allergens against the background of basic pharmacotherapy allows to reduce the severity of AR and BA symptoms in 65 % of patients already 1 year after the start of its implementation. Sensitization to the major canine allergen Can f1 is accompanied by better results in controlling the symptoms of these diseases. The level of sIgG4-antibodies is a reliable diagnostic marker of the effectiveness of ASIT with dog allergens already 1 year after the start of treatment. The question of the effectiveness of ASIT with dog allergens requires further study with an analysis of its results 3-5 years after the start of treatment. Key words: allergic rhinitis, bronchial asthma, hypersensitivity, dog allergens, allergen-specific immunotherapy.","PeriodicalId":492951,"journal":{"name":"Astma ta alergìâ","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of Allergen-Specific Immunotherapy in Patients with Allergic Rhinitis and/or Bronchial Asthma with Hypersensitivity to Dog allergens. Data of the First Year of Observation\",\"authors\":\"M. A. Lykova, S.V. Zaikov\",\"doi\":\"10.31655/2307-3373-2023-3-42-48\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract. Allergen-specific immunotherapy (ASIT) is the only available treatment method aimed at the pathophysiology of allergic diseases, which can modify the course of the disease. However, in the case of hypersensitivity to dog allergens, data on the effectiveness of ASIT are contradictory. The aim of the study: to study the effectiveness of ASIT in patients with allergic rhinitis (AR) and/or bronchial asthma (BA) and hypersensitivity to dog allergens. Materials and methods. The level of specific IgG4 (sIgG4) to dog extract allergens was determined before and one year after the start of treatment, and the results of a questionnaire on symptom control were analyzed in 15 patients with RA, 3 patients with BA, and 5 patients with a combination of RA with BA The results. After 1 year of treatment with ASIT with a dog dander allergen, 9 out of 15 (60 %) patients with AR reported the absence of symptoms. In addition, these individuals had an increase in the level of sIgG4 to the extract of the corresponding allergen. Only 4 (26.6 %) patients with AR noted the onset of rhinitis symptoms only during long-term contact with dogs and controlled these symptoms with the help of antihistamines. In 2 patients, positive dynamics of symptoms were not observed and the level of sIgG did not change relative to the initial level. In all patients with BA, symptoms were well controlled against the background of basic therapy, and a slight increase in sIgG4-antibodies was registered in all examined patients. Among 5 people with a combination of AR and BA, 3 (60 %) patients noted the absence of rhinitis symptoms and good control of BA with the help of basic therapy, and in 2 (40 %) of the examined, the severity of symptoms of both rhinitis and asthma did not change significantly after undergoing therapy. The average increase in the level of sIgG4 was 2.5 mg/l. The majority of patients with positive test results for sIgG4 were monosensitized to the main component of canine lipocalin Can f1 (8 of 15 patients). As for the patients in whom ASIT was insufficiently effective, all of them (4 persons) were sensitized to both the main dog allergens Can f1 and Can f5. Conclusions. ASIT with dog allergens against the background of basic pharmacotherapy allows to reduce the severity of AR and BA symptoms in 65 % of patients already 1 year after the start of its implementation. Sensitization to the major canine allergen Can f1 is accompanied by better results in controlling the symptoms of these diseases. The level of sIgG4-antibodies is a reliable diagnostic marker of the effectiveness of ASIT with dog allergens already 1 year after the start of treatment. The question of the effectiveness of ASIT with dog allergens requires further study with an analysis of its results 3-5 years after the start of treatment. Key words: allergic rhinitis, bronchial asthma, hypersensitivity, dog allergens, allergen-specific immunotherapy.\",\"PeriodicalId\":492951,\"journal\":{\"name\":\"Astma ta alergìâ\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Astma ta alergìâ\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31655/2307-3373-2023-3-42-48\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Astma ta alergìâ","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31655/2307-3373-2023-3-42-48","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

摘要过敏原特异性免疫治疗(ASIT)是目前唯一针对变态反应性疾病病理生理的治疗方法,可以改变疾病的病程。然而,在对狗过敏原过敏的情况下,关于ASIT有效性的数据是矛盾的。本研究的目的:研究ASIT对变应性鼻炎(AR)和/或支气管哮喘(BA)及犬过敏原过敏患者的疗效。材料和方法。测定15例RA患者、3例BA患者和5例RA合并BA患者在治疗前和治疗后1年对犬提取物过敏原的特异性IgG4 (sIgG4)水平,并对症状控制问卷结果进行分析。在用带有狗皮屑过敏原的ASIT治疗1年后,15例AR患者中有9例(60%)报告症状消失。此外,这些个体对相应过敏原提取物的sIgG4水平升高。只有4例(26.6%)的AR患者在与狗长期接触时才出现鼻炎症状,并在抗组胺药的帮助下控制了这些症状。在2例患者中,未观察到症状的阳性动态,sIgG水平相对于初始水平没有变化。在所有BA患者中,在基础治疗的背景下,症状得到了很好的控制,所有检查的患者中sigg4抗体均略有升高。在5例合并AR和BA的患者中,3例(60%)患者在基础治疗的帮助下鼻炎症状消失,BA得到良好控制,2例(40%)患者接受治疗后鼻炎和哮喘症状的严重程度无明显变化。sIgG4水平平均升高2.5 mg/l。大多数sIgG4阳性的患者对犬脂钙素Can f1的主要成分单致敏(15例患者中有8例)。ASIT效果不足的患者(4人)均对犬主要变应原Can f1和Can f5均致敏。结论。在基础药物治疗的背景下,狗过敏原ASIT在开始实施一年后,可以减轻65%的患者的AR和BA症状的严重程度。对主要犬过敏原Can f1增敏,在控制这些疾病的症状方面效果较好。sigg4抗体水平是一种可靠的诊断标记物,在治疗开始1年后,狗过敏原ASIT的有效性。ASIT对狗过敏原的有效性问题需要进一步研究,并在治疗开始后3-5年对其结果进行分析。关键词:变应性鼻炎,支气管哮喘,超敏反应,犬过敏原,过敏原特异性免疫治疗
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness of Allergen-Specific Immunotherapy in Patients with Allergic Rhinitis and/or Bronchial Asthma with Hypersensitivity to Dog allergens. Data of the First Year of Observation
Abstract. Allergen-specific immunotherapy (ASIT) is the only available treatment method aimed at the pathophysiology of allergic diseases, which can modify the course of the disease. However, in the case of hypersensitivity to dog allergens, data on the effectiveness of ASIT are contradictory. The aim of the study: to study the effectiveness of ASIT in patients with allergic rhinitis (AR) and/or bronchial asthma (BA) and hypersensitivity to dog allergens. Materials and methods. The level of specific IgG4 (sIgG4) to dog extract allergens was determined before and one year after the start of treatment, and the results of a questionnaire on symptom control were analyzed in 15 patients with RA, 3 patients with BA, and 5 patients with a combination of RA with BA The results. After 1 year of treatment with ASIT with a dog dander allergen, 9 out of 15 (60 %) patients with AR reported the absence of symptoms. In addition, these individuals had an increase in the level of sIgG4 to the extract of the corresponding allergen. Only 4 (26.6 %) patients with AR noted the onset of rhinitis symptoms only during long-term contact with dogs and controlled these symptoms with the help of antihistamines. In 2 patients, positive dynamics of symptoms were not observed and the level of sIgG did not change relative to the initial level. In all patients with BA, symptoms were well controlled against the background of basic therapy, and a slight increase in sIgG4-antibodies was registered in all examined patients. Among 5 people with a combination of AR and BA, 3 (60 %) patients noted the absence of rhinitis symptoms and good control of BA with the help of basic therapy, and in 2 (40 %) of the examined, the severity of symptoms of both rhinitis and asthma did not change significantly after undergoing therapy. The average increase in the level of sIgG4 was 2.5 mg/l. The majority of patients with positive test results for sIgG4 were monosensitized to the main component of canine lipocalin Can f1 (8 of 15 patients). As for the patients in whom ASIT was insufficiently effective, all of them (4 persons) were sensitized to both the main dog allergens Can f1 and Can f5. Conclusions. ASIT with dog allergens against the background of basic pharmacotherapy allows to reduce the severity of AR and BA symptoms in 65 % of patients already 1 year after the start of its implementation. Sensitization to the major canine allergen Can f1 is accompanied by better results in controlling the symptoms of these diseases. The level of sIgG4-antibodies is a reliable diagnostic marker of the effectiveness of ASIT with dog allergens already 1 year after the start of treatment. The question of the effectiveness of ASIT with dog allergens requires further study with an analysis of its results 3-5 years after the start of treatment. Key words: allergic rhinitis, bronchial asthma, hypersensitivity, dog allergens, allergen-specific immunotherapy.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信