Cdx转录因子特性的优化

IF 0.6
Taraneh Javanbakht
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引用次数: 0

摘要

本研究提出了TOPSIS在转录因子特性优化方面的新应用。这个应用程序是必不可少的,因为它可以帮助比较这些蛋白质的特性,并确定与该决策方法比较的最佳输出。本文的假设是,根据前人对Cdx转录因子的研究,由于Cdx2转录因子比Cdx1和Cdx4表现出更强的特性,因此TOPSIS方法比其他两种方法更能显示出这些第一蛋白的排名位置。此外,与使用相应质粒生产Cdx1、Cdx2和Cdx4转录因子诱导的基因表达调控相比,质粒中使用的嵌入抑制域EnRCdx1显示pax3基因表达减少,该抑制域TOPSIS的最差排名位置预计为。排序方法的结果表明,转录因子和阻遏子结构域的排序位置与其比较性质相对应。候选方案权重值的变化表明候选方案与最佳方案和最差方案的距离以及接近系数的变化。然而,正如预期的那样,候选因子的排名位置没有变化,Cdx2转录因子仍然是最佳候选因子。本文的研究结果可用于计算机工程,以提高这些蛋白质的生物学应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimization of Cdx Transcription Factors Characteristics
This study presents a new application of TOPSIS for the optimization of transcription factors characteristics. This application is essential as it can help compare the characteristics of these proteins and determine the optimized output of their comparison with this decision-making method. The hypothesis in this article was that according to the previous study of the Cdx transcription factors, as the Cdx2 transcription factor showed more robust characteristics than Cdx1 and Cdx4, the TOPSIS method would show a better rank position of these first proteins in comparison with the two other ones. Moreover, the engrailed repressor domain EnRCdx1 used in the plasmid showed the reduction of the pax3 gene expression in comparison with the induced regulation of the gene expression with the production of the Cdx1, Cdx2, and Cdx4 transcription factors using the corresponding plasmids, the worst rank position with TOPSIS was expected for this repressor domain. The results obtained with this ranking method showed that the rank positions of the transcription factors and the repressor domain corresponded to their compared properties. Moreover, the change in the weight values of the candidates showed the modification of their distances from the best and worst alternatives and closeness coefficients. However, as expected, the candidates’ rank positions were unchanged, and the Cdx2 transcription factor was still the best candidate. The results of this article can be used in computer engineering to improve biological applications of these proteins.
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
15
审稿时长
12 weeks
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