苯甲酸和炔基二步法合成异喹诺酮类药物及其与异香豆素的比较发光研究

ИНЭОС OPEN Pub Date : 2023-10-12 DOI:10.32931/io2228a

V. B. Kharitonov, M. A. Arsenov, A. A. Danshina, D. A. Loginov

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引用次数: 0

摘要

以苯甲酸与炔烃的碳氢环反应为基础，再对甲酸铵生成的异香豆素进行处理，建立了一种高效的两步法合成异喹诺酮类化合物(异喹诺酮-1(2H)-酮)。将该方法应用于天然异喹诺酮胺A的合成。光学性质的比较研究表明，异喹诺酮类化合物比异香豆素类化合物具有更强的发光能力。

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Facile Two-Step Synthesis of Isoquinolones from Benzoic Acids and Alkynes and Their Comparative Photoluminescent Study vs Isocoumarins

An efficient two-step protocol for the synthesis of isoquinolones (isoquinolin-1(2H)-ones) has been developed based on the C–H annulation of benzoic acids with alkynes followed by the treatment of the isocoumarins formed with ammonium formate. This approach was applied for the synthesis of naturally occurring isoquinolone siaminine A. A comparative study of the optical properties revealed that isoquinolones display stronger luminescence emission than isocoumarins.

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