不明原因复发性流产的免疫平衡与基因多态性研究进展

Yafei Kang, Qinying Xie, Shuting Chen, Qinlan Li, Xinyi Dong, Tianyu Zhang, Sen Fu, Qinghua Lei, Donghui Huang
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引用次数: 0

摘要

复发性自然流产(RSA)的病因非常复杂,有40-50%的患者有不明原因的流产,称为不明原因的RSA (URSA)。URSA影响约1-2%的育龄女性,对患者及其家人的身心状况产生巨大影响。该病的发病机制尚不清楚,使其治疗变得复杂。近年来,对URSA免疫平衡机制的探索取得了相当大的进展,普遍认为免疫反应平衡(如免疫异常)可能是妊娠结局不佳的根本原因。本文就免疫细胞和阻断抗体(BAs)在URSA中的作用进行综述。此外,由于遗传多态性在URSA发病机制中的作用已被深入研究,分子遗传学在URSA的发病率中也起着至关重要的作用。然而,这些研究的结果是不一致的,特别是在不同的人群中。本文综述了以往URSA与母体遗传多态性的研究,重点总结了目前最重要的发现,并对有临床症状的URSA患者提供诊断建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research progress of immune balance and genetic polymorphism in unexplained recurrent abortion
The etiology of recurrent spontaneous abortion (RSA) is extremely complex, as there are 40–50% of patients with unexplained miscarriages, known as unexplained RSA (URSA). URSA affects approximately 1–2% of females of childbearing age and has a massive impact on the physical and mental conditions of both patients and their families. The pathogenesis of the disease remains unclear, making its treatment complicated. In recent years, considerable progress has been made in the exploration of the URSA immune balance mechanism and it has been universally acknowledged that a balanced immune response (as abnormal immunity) may be the root cause of poor pregnancy outcomes. This review discussed and summarized the effects of immune cells and blocking antibodies (BAs) on URSA based on the current state of knowledge in this area. Additionally, molecular genetics also plays an essential role in the incidence rate of URSA since the role of genetic polymorphism in the pathogenesis of URSA has been thoroughly studied. Nonetheless, the outcomes of these studies are inconsistent, particularly across populations. This paper reviewed previous studies on URSA and maternal genetic polymorphism, focusing on and synthesizing the most important findings to date, and providing diagnostic recommendation for URSA patients with clinical symptoms.
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