苯和羟胺直接生成苯胺

Q3 Chemistry

Chemistry Pub Date : 2023-09-23 DOI:10.3390/chemistry5040139

Ningyu Liu, Matthew D. Sleck, William D. Jones

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引用次数: 0

摘要

研究了一种单步合成苯胺的方法。以钒酸盐为催化剂，氧化铁为助催化剂，盐酸羟胺为胺源，苯胺收率高达90%，选择性高。进一步研究表明，整个反应在羟胺浓度上为准二级反应。区域选择性H-D交换实验表明，C-N键的形成是通过不可逆的亲电途径进行的。基于所有的关键观察，提出了一种机制。

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Direct Aniline Formation with Benzene and Hydroxylamine

A single-step method for aniline formation was examined. Using a vanadate catalyst with an iron oxide co-catalyst and hydroxylamine hydrochloride as the amine source, an up to 90% yield of aniline was obtained with high selectivity. Further study showed that the overall reaction was pseudo-second order in terms of hydroxylamine concentration. Regioselective H-D exchange experiments suggest that the C-N bond formation step occurs via an irreversible electrophilic pathway. Based on all of the key observations, a mechanism is proposed.

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来源期刊

Chemistry

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2017 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields.