将Icrp ir模型集成到idos2剂量测定系统中

Q4 Medicine
V.V. Vostrotin
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引用次数: 0

摘要

iDose 2剂量测量系统是在当前个人剂量控制(IDC)下评估工人内照射剂量的工具。在该系统中,根据对生物物体(包括未超过测量技术检测限度的物体)中放射性核素活度的一系列测量以及接触时间和化合物类型的信息,根据贝叶斯方法估计内部照射的承诺有效剂量当量(CEDE)及其不确定度。实际上,在不改变源代码的情况下,可以将放射性核素在人体内的行为的任何生物动力学模型,以常微分方程(ode)系统的形式呈现,在隔室之间具有恒定的过渡系数,整合到iDose 2剂量测定系统中。目的:整合来自ICRP出版物100、130、134、137和141的放射性核素清单(通常称为放射性核素职业摄入量系列(OIR))的新的组合生物动力学模型,用于AMAD = 1和5微米的摄入和吸入途径。材料和方法:对于生物动力学模型的每个变体,通过描述ODE系统的矩阵的特征向量和特征值找到放射性核素的保留/去除功能。结果:共整合了65个新的生物动力学模型和180个指数和形式的放射性核素保留/去除函数,并进行了质量控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integration of Icrp Oir Models Into the iDose 2 Dosimetry System
Introduction: The iDose 2 dosimetry system is a tool for assessing the doses of internal irradiation of workers under the current individual dosimetry control (IDC). In this system, according to a series of measurements of the activity of radionuclides in biological objects (including those not exceeding the detection limit of the measurement technique) and information on contact times and types of compounds, estimates of the committed effective dose equivalent (CEDE) of internal irradiation, as well as their uncertainties, are made based on the Bayesian approach. It is possible to integrate practically any biokinetic models of the behavior of radionuclides in the human body, presented in the form of a system of ordinary differential equations (ODEs) with constant transition coefficients between compartments, into the iDose 2 dosimetry system without changing the source code. Purpose: Integration of new combined biokinetic models for the list of radionuclides: H-3, Sr-90, Cs-137, Pu-238, Pu-239 and Am-241 from Publications 100, 130, 134, 137 and 141 of the ICRP (conventionally called the series Occupational Intakes of Radionuclides (OIR)), for ingestion and inhalation routes of intake with AMAD = 1 and 5 microns. Material and methods: For each variant of the biokinetic model, the functions of retention/removal of radionuclides were found through the eigenvectors and eigenvalues of the matrix describing the ODE system. Results: A total of 65 new biokinetic models and 180 functions of radionuclide retention/removal in the form of a sum of exponents were integrated and quality control was carried out.
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来源期刊
Medical Radiology and Radiation Safety
Medical Radiology and Radiation Safety Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.40
自引率
0.00%
发文量
72
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