尼日利亚治疗中心艾滋病毒/艾滋病感染者的结核病负担及其预测因素:一项前瞻性研究

Q4 Medicine

Rwanda Medical Journal Pub Date : 2023-10-13 DOI:10.4314/rmj.v80i3.6

S. A. Olowookere, O. F. Awopeju, F. O. Fehintola, O. Arije, T. O. Ojo, O. I. Obe-Adeoye, O. A. Aina, M. O. Gbadamosi, E. G. Adepoju

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引用次数: 0

摘要

& # x0D;& # x0D;& # x0D;简介:结核病(TB)仍然是艾滋病毒/艾滋病(PLWHA)感染者死亡的主要原因。本研究评估了在尼日利亚Osogbo国家专科医院接受治疗的艾滋病感染者的结核病负担及其预测因素。方法:对2009年2月至2019年12月临床筛查结核病的PLWHA患者进行前瞻性研究。收集的信息包括他们的社会人口统计学特征、其他变量、结核病体征和症状以及CD4计数。至少有一种结核症状或体征的感染者接受了实验室诊断。数据分析采用描述性统计和推理统计。结果:在研究期间，共有4057名PLWHA患者进行了结核病临床筛查。男性982例(24.2%)，女性3075例(75.8%)。698人(33.4%)被诊断为结核。logistic回归分析显示，结核病的预测因素包括女性(AOR=3.53, 95%CI=2.72 ~ 4.59, p<0.001)、受教育程度较低(AOR=2.53, 95%CI=2.07 ~ 3.10, p<0.001)、社会经济地位低(AOR=34.54, 95%CI=21.10 ~ 56.52, p=0.0001)、体重过轻(AOR=3.28, 95%CI=2.69 ~ 4.10, p<0.001)、CD4计数200/ml (AOR=3.69, 95%CI=3.04 ~ 4.47, p<0.001)。结论:艾滋病患者结核病负担高，其预测因素包括社会经济地位低、女性、受教育程度低、CD4计数低和体重过轻。解决这些因素可减轻艾滋病感染者的结核病负担。& # x0D;& # x0D;

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Tuberculosis burden and its predictors among people living with HIV/AIDS at a Nigerian treatment centre: a prospective study

INTRODUCTION: Tuberculosis (TB) remains a major cause of death in people living with HIV/AIDS (PLWHA). This study assessed TB burden and its predictors among PLWHA receiving care at the State Specialist Hospital, Osogbo, Nigeria.METHODS: A prospective study was conducted among PLWHA screened clinically for TB from February 2009 till December 2019. Information collected included their socio-demographic characteristics, other variables, TB signs and symptoms, and CD4 count. PLWHA with at least one TB symptom or sign underwent laboratory diagnosis. Data were analyzed using descriptive and inferential statistics. RESULTS: A total of 4057 PLWHA were screened clinically for TB during the study period. They were 982 (24.2%) males and 3075 (75.8%) females. Six hundred and ninety-eight (33.4%) were diagnosed with TB. On logistic regression analysis, predictors of TB included being female (AOR=3.53, 95%CI=2.72-4.59, p<0.001), having lower education (AOR=2.53, 95%CI=2.07-3.10, p<0.001), having low socio-economic status (AOR=34.54, 95%CI=21.10-56.52, p=0.0001), being underweight (AOR=3.28, 95%CI=2.69-4.10, p<0.001) and having CD4 count <200/ml (AOR=3.69, 95%CI=3.04-4.47, p<0.001). CONCLUSION: PLWHA had a high TB burden with predictors including low socio-economic status, being female, having had lower education, low CD4 count, and being underweight. Addressing these factors may reduce the TB burden among PLWHA.

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来源期刊

Rwanda Medical Journal Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： The Rwanda Medical Journal (RMJ), is a Not-For-Profit scientific, medical, journal that is published entirely online in open-access electronic format. The RMJ is an interdisciplinary research journal for publication of original work in all the major health disciplines. Through a rigorous process of evaluation and peer review, The RMJ strives to publish original works of high quality for a diverse audience of healthcare professionals. The Journal seeks to deepen knowledge and advance scientific discovery to improve the quality of care of patients in Rwanda and internationally.