{"title":"蜂胶对奥沙利铂致白化大鼠妊娠前期和妊娠期发育毒性的潜在改善作用","authors":"Zeinab Kamal, Ebnalwaled Ahmed, Dorreia Zaghloul, Zeinab Al-Amgad, Amany Mohamed","doi":"10.21608/ejz.2023.231135.1103","DOIUrl":null,"url":null,"abstract":", the groups 2, 3, and 4 received PRO (200 mg/kg body weight, orally/daily), OXA (3 mg/kg body weight, intravenous injection, three times/week), OXA+PRO, respectively, for 21 days pre-pregnancy; while, the groups 5, 6, and 7 received the same treatments and doses for 21 days during pregnancy. The results of the current study showed that – as compared to the OXA-induced renal and splenic toxicity in maternal rats and their neonates – co-administration of PRO with OXA either prior or during pregnancy conferred a crucial protective role to overwhelm the OXA-induced histopathological alterations in the renal and spleen tissues.","PeriodicalId":11659,"journal":{"name":"Egyptian Journal of Zoology","volume":"76 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"POTENTIAL AMELIORATIVE EFFECT OF PROPOLIS AGAINST THE DEVELOPMENTAL TOXICITY INDUCED BY OXALIPLATIN IN ALBINO RATS PRIOR AND DURING PREGNANCY\",\"authors\":\"Zeinab Kamal, Ebnalwaled Ahmed, Dorreia Zaghloul, Zeinab Al-Amgad, Amany Mohamed\",\"doi\":\"10.21608/ejz.2023.231135.1103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\", the groups 2, 3, and 4 received PRO (200 mg/kg body weight, orally/daily), OXA (3 mg/kg body weight, intravenous injection, three times/week), OXA+PRO, respectively, for 21 days pre-pregnancy; while, the groups 5, 6, and 7 received the same treatments and doses for 21 days during pregnancy. The results of the current study showed that – as compared to the OXA-induced renal and splenic toxicity in maternal rats and their neonates – co-administration of PRO with OXA either prior or during pregnancy conferred a crucial protective role to overwhelm the OXA-induced histopathological alterations in the renal and spleen tissues.\",\"PeriodicalId\":11659,\"journal\":{\"name\":\"Egyptian Journal of Zoology\",\"volume\":\"76 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Zoology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/ejz.2023.231135.1103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Zoology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ejz.2023.231135.1103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
POTENTIAL AMELIORATIVE EFFECT OF PROPOLIS AGAINST THE DEVELOPMENTAL TOXICITY INDUCED BY OXALIPLATIN IN ALBINO RATS PRIOR AND DURING PREGNANCY
, the groups 2, 3, and 4 received PRO (200 mg/kg body weight, orally/daily), OXA (3 mg/kg body weight, intravenous injection, three times/week), OXA+PRO, respectively, for 21 days pre-pregnancy; while, the groups 5, 6, and 7 received the same treatments and doses for 21 days during pregnancy. The results of the current study showed that – as compared to the OXA-induced renal and splenic toxicity in maternal rats and their neonates – co-administration of PRO with OXA either prior or during pregnancy conferred a crucial protective role to overwhelm the OXA-induced histopathological alterations in the renal and spleen tissues.
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