首次使用贝克酵母高效简便地合成一锅多组分贝蒂碱

IF 2.4 3区化学 Q2 CHEMISTRY, ORGANIC

Polycyclic Aromatic Compounds Pub Date : 2024-09-13 DOI:10.1080/10406638.2023.2265022

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引用次数: 0

摘要

在贝克酵母（BY）作为高效催化剂和乙醇作为绿色溶剂存在的情况下，可以绿色简便地合成 1-(α-氨基烷基)-2-萘酚（通常称为贝蒂碱（BB））。在此方法中，BY 首次用作生物催化剂（酶）。该方法具有一些固有的优点，如反应条件温和、无环境污染、操作简单、无需柱层析、反应物多样化，并能以良好到极佳的收率获得所需的 1-(α-氨基烷基)-2-萘酚（贝蒂碱）（4a-r）。这是有关贝克酵母催化（BYC）合成 BB 的首次报道。这种在生物催化剂（如 BY）存在下合成 BB 的生物催化路线有望为合成含有 BB 的复合生物活性分子开辟一条途径。

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Efficient and Facile One-Pot Multi-Component Synthesis of Betti Bases Using Baker’s Yeast for the First Time

A green and facile synthesis of 1-(α-aminoalkyl)-2-naphthols, generally called Betti bases (BB) in the presence of Baker’s yeast (BY), acts as an efficient catalyst, and ethanol as a green solvent. In this methodology, the BY is used first time as a biocatalyst (enzyme). This protocol has some inherent advantages, such as mild reaction conditions, no environmental pollution, simple work up, no need of column chromatography, diversity of reactant and desired 1-(α-aminoalkyl)-2-naphthols (Betti bases) (4a-r) are obtained in good-to-excellent yields. This is the first report on Baker’s yeast-catalyzed (BYC) synthesis for BB. This present bio-catalytical route for synthesizing BB in the presence of biocatalysts like BY is anticipated to open a gateway to synthesized complexed biological active molecules counting BB.

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来源期刊

Polycyclic Aromatic Compounds 化学-有机化学

CiteScore

3.70

自引率

20.80%

发文量

412

审稿时长

3 months

期刊介绍： The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.