强调多组学方法在提高乳腺癌和前列腺癌患者生存率中的作用

Khushali Upadhyay, Foram Patel, Yashshvini Patel, A. V. Ramachandran, Darshee Baxi
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引用次数: 0

摘要

自从基因组学出现以来,对癌症生物学的理解已经有了很大的进步。即使在组织学上具有可比性的癌症中,也存在着全基因组(或组学)水平上的显著异质性,这表明了癌症基因组的巨大复杂性。一个有潜力将高通量组学转化为更好和更快的总体生存的强大资源是多组学数据库的大量累积和公共可访问性,附带临床注释,包括肿瘤组织学,患者反应和结果。在这个高通量组学的新时代,本文强调了多维基因组分析方法的独特好处。它讨论了翻译组学研究对癌症人群的影响。高通量技术的单级数据分析具有局限性,因为它只显示细胞过程的一个小窗口。通过不同平台(包括基因组、表观基因组学、转录组学、蛋白质组学和代谢组学)的数据集成,了解多个细胞组织水平之间的联系是很重要的。本文综述了几种流行的集成多组学数据的框架。它概述了多组学在肿瘤分类、预后、诊断方面的应用,以及在寻找新的生物标志物和治疗方案方面的数据集成功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emphasizing the Role of Multi-omics Approach to Increase Survival Rate of Breast and Prostate Cancer Patients
The understanding of cancer biology has greatly advanced since the advent of genomics. A remarkable heterogeneity at the whole-genome (or omics) level exists amongst even histologically comparable cancers, demonstrating the enormous complexity of the cancer genome. A powerful resource that has the potential to translate high-throughput omics to better and quick overall survival is the massive accrual and public accessibility of multi-omics databases with accompanying clinical annotation, including tumor histology, patient response, and outcome. In this new era of high-throughput omics, this paper emphasizes the distinct benefits of a multidimensional approach to genomic analysis. It discusses the implications of translational omics research for the cancer population. Single-level data analysis of high-throughput technologies has constraints because it only displays a small window of cellular processes. Understanding the links across several cellular organization levels made possible by data integration across various platforms, including genomes, epigenomics, transcriptomics, proteomics, and metabolomics, is important. This review examines a few popular frameworks for integrating multi-omics data. It provides a general overview of multi-omics applications in tumor classification, prognosis, diagnostics, and the function of data integration in searching for novel biomarkers and treatment options.
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