羟基磷灰石-粘土复合材料用于骨组织工程:对虾外骨骼生物废弃物的有效利用

Perabathula Satish, Komalakrushna Hadagalli, Lakkimsetti Lakshmi Praveen, Mahin Saif Nowl, Asiful H. Seikh, Ibrahim A. Alnaser, Hany S. Abdo, Saumen Mandal
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摘要

羟基磷灰石(HA, Ca10(PO4)6(OH)2)基多孔支架在过去的三十年中得到了广泛的研究。透明质酸具有良好的生物相容性和骨导电性,在骨组织工程中得到了广泛的应用。为了提高HA的力学生物学性能,添加粘土制备HA基复合支架引起了研究人员的极大兴趣。在本研究中,通过机械混合方法证明了一种成本效益高的制备ha -粘土复合材料的方法,其中高岭土因其生物相容性而被使用。以印度对虾(Fenneropenaeus indicus)外骨骼废弃物为原料,采用湿法化学合成法合成纯透明质酸。分别用10%、20%和30% wt.%的高岭土增强HA,通过机械搅拌法制备HA -粘土复合材料。通过XRD、FTIR、Raman、FESEM等一系列表征工具的分析,分别确定了烧结裸HA、HA -高岭土复合粘土和单独高岭土的物相、特征结构和振动键以及形貌。将HA -粘土复合球团在1100℃下单轴加压烧结2 h,进行压缩试验,与裸HA相比,HA -高岭土复合球团的机械和物理性能均有提高,抗压强度最高达35 MPa,开放孔隙率为33%。与裸HA相比,添加20%高岭土的HA抗压强度提高了33.7%,开放孔隙率提高了19%。不同高岭土(10%、20%、30% wt.%)对羟基磷灰石的补强,为骨组织工程领域制备力学性能增强、磨损改善、细胞增殖改善的生物复合材料支架开辟了新的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hydroxyapatite–Clay Composite for Bone Tissue Engineering: Effective Utilization of Prawn Exoskeleton Biowaste
Hydroxyapatite (HA, Ca10(PO4)6(OH)2)-based porous scaffolds have been widely investigated in the last three decades. HA, with excellent biocompatibility and osteoconductivity, has made this material widely used in bone tissue engineering. To improve the mechano-biological properties of HA, the addition of clay to develop HA-based composite scaffolds has gained considerable interest from researchers. In this study, a cost-effective method to prepare a HA–clay composite was demonstrated via the mechanical mixing method, wherein kaolin was used because of its biocompatibility. Prawn (Fenneropenaeus indicus) exoskeleton biowaste was utilized as a raw source to synthesize pure HA using wet chemical synthesis. HA–clay composites were prepared by reinforcing HA with 10, 20, and 30 wt.% of kaolin via the mechanical mixing method. A series of characterization tools such as XRD, FTIR, Raman, and FESEM analysis confirmed the phases and characteristic structural and vibrations bonds along with the morphology of sintered bare HA, HA–kaolin clay composite, and kaolin alone, respectively. The HA–clay composite pellets, uniaxially pressed and sintered at 1100 °C for 2 h, were subjected to a compression test, and an enhancement in mechanical and physical properties, with the highest compressive strength of 35 MPa and a retained open porosity of 33%, was achieved in the HA–kaolin (20 wt.%) clay composite, in comparison with bare HA. The addition of 20% kaolin to HA enhanced its compressive strength by 33.7% and increased its open porosity by 19% when compared with bare HA. The reinforcement of HA with different amounts (10, 20, 30 wt.%) of kaolin could open up a new direction of preparing biocomposite scaffolds with enhanced mechanical properties, improved wear, and better cell proliferation in the field of bone tissue engineering.
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