胰腺导管腺癌(肠型分化)表现为卵巢转移:1例报告

Emily Fronk, Annalyn Welp, Megan Dibbern, Anne Mills, Leigh Cantrell
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引用次数: 0

摘要

摘要:胰腺腺癌转移到卵巢并不常见,其临床表现与原发性卵巢疾病相似,给诊断带来了挑战。免疫组织化学染色通常用于区分卵巢原发和卵巢转移。一种较新的和罕见的胰腺腺癌变异,具有肠型分化,以前没有报道转移到卵巢。由于与原发卵巢肿瘤的染色模式重叠,其诊断特别困难。病例报告:本病例报告提出的情况下,60岁的女性谁提出了非特异性腹部症状,并发现有一个大的附件肿块。影像学显示腹膜、胰腺和肝脏有其他病变。她接受了活检,形态学和免疫组织化学染色与肠型分化的胰腺导管腺癌一致。她开始接受FOLFIRINOX治疗,但由于疾病进展,最终选择了舒适护理。结论:虽然罕见,但据我们所知,这是第一次报道这种疾病过程,临床医生应该意识到这种可能性,因为它会影响治疗的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pancreatic ductal adenocarcinoma (intestinal-type differentiation) presenting as ovarian metastases: A case report
Introduction: Metastasis of pancreatic adenocarcinoma to the ovaries is uncommon and can clinically present similarly to primary ovarian disease, presenting challenges for diagnosis. Immunohistochemical staining is typically useful in distinguishing ovarian primaries from ovarian metastasis. A newer and rarer variant of pancreatic adenocarcinoma, that with intestinal-type differentiation, has not previously been reported as metastasizing to the ovary. Its diagnosis is particularly difficult due to the overlap in staining patterns with primary ovarian neoplasms. Case Report: This case report presents the case of a 60-year-old female who presented with non-specific abdominal symptoms and was found to have a large adnexal mass. Imaging showed additional lesions in the peritoneum, pancreas, and liver. She underwent biopsy with morphology and immunohistochemical staining consistent with pancreatic ductal adenocarcinoma with intestinal-type differentiation. She was started on FOLFIRINOX therapy but ultimately opted to pursue comfort care due to disease progression. Conclusion: Although rare, with this being the first report of this disease course to our knowledge, clinicians should be aware of this possibility, as it impacts choice of treatment.
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