Experience in the use of endovenous methods and cell technologies in the treatment of trophic defects in patients with chronic venous insufficiency C6

Introduction: Chronic venous insufficiency (CVI) occurs in 25-40% of the adult population with the severe forms of CEAP C3–C6 in 17-20% of cases. Study aimed to compare the standard treatment of CVI and the use of endovenous methods, cellular technologies.Materials and methods: I group - 28 patients were treated using modern wound coverings, cell technologies and performing minimally invasive operations. II group - 42 patients underwent crossectomy with stripping of the trunk of the target vein and local treatment with "standard" ointments. Treatment results were evaluated using Venous Clinical Severity Score (VCSS), Numeric Pain Rating Scale (NPRS) and ulcer healing time.Results: After 1 month VCSS score was 13.82.3 and 16.43.3 points in I and II groups; after 3 months, 10.22.1 and 13.62.4 points. VLU was healed in 20 (71.43%) and 16 patients (38%) after 3 months in I and II groups, in 26 (92.86%) and 30 patients (71.43%) after 6 months; 28 (100%) and 40 patients (95.24%) after 12 months. After 1, 3 and 6 months occlusion of the target segment was achieved in 14 (100%) patients of the I group. NPRS scale was significantly lower in patients of I group. In patients of the I group, the hospital stay was 8.22.4 days, II group - 14.53.8 days.Conclusions: The use of modern wound coverings, Platelet Rich Plasma (PRP) and Negative-pressure wound therapy (NPWT) therapy, reduce the period of preoperative preparation, speed up the stage of cleaning and healing of VLU compared to conventional wound coverings.