大颗粒淋巴细胞白血病治疗结果分析:印度回顾性研究

IF 0.6 Q4 ONCOLOGY
Mir Sadaqat Hassan Zafar, Sajad Ahmad Geelani, Javid Rasool Bhat
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引用次数: 0

摘要

根据世界卫生组织的分类,大颗粒淋巴细胞(LGL)白血病是一种罕见的惰性淋巴细胞增生性疾病,属于成熟T细胞和自然杀伤(NK)细胞肿瘤。本文评估对免疫抑制治疗的反应。在这项回顾性研究中,在两个三级医疗机构评估和治疗的各种慢性淋巴细胞增生性疾病(clpd)病例被筛选并进行亚分析。在满足LGL白血病标准后,进一步评估病例的表现特征和对治疗的反应。统计分析使用统计软件包为社会科学,版本23进行。在分析的384例clpd中,14例(3.64%)被鉴定为LGL白血病并进行进一步分析。男性6例(42.85%),女性8例(57.14%)(M: F = 1:1.33),年龄42 ~ 82岁。T-LGL型13例(92.85%),NK-LGL型1例(7.14%)。贫血是最常见的表现(92.85%),其次是淋巴细胞增多(85.71%)和中性粒细胞减少(78.57%)。血小板减少4例(28.57%),全血细胞减少2例(14.28%)。脾肿大2例(14.28%),淋巴结病变1例(7.14%)。1例(7.14%)有类风湿关节炎,1例(7.14%)有复发性胸部感染。14例患者中,完全缓解5例(35.71%),部分缓解5例(35.71%),一线治疗耐药2例,密切随访2例(仅观察)。总有效率为83.33%。这项研究强调了免疫抑制治疗一种罕见的淋巴细胞增生性疾病的优异反应率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Treatment Outcome in Large Granular Lymphocytic Leukemia: A Retrospective Study from India
Large granular lymphocytic (LGL) leukemia is a rare and indolent lymphoproliferative disorder that belongs to mature T and natural killer (NK) cell neoplasms, as per the World Health Organization classification. This article assesses the response to immunosuppressive therapy. In this retrospective study, various cases of chronic lymphoproliferative disorders (CLPDs) evaluated and treated in two tertiary care settings were screened and taken for subanalyses. After fulfilling the criteria for LGL leukemia, cases were further assessed for presenting features and response to treatment. Statistical analysis was performed using the Statistical Package for the Social Sciences, version 23. Out of 384 cases of CLPDs analyzed, 14 cases of LGL leukemia were identified (3.64%) and subjected to further analysis. There were six males (42.85%) and eight females (57.14%) (M: F = 1:1.33) with an age group ranging from 42 to 82 years. Thirteen cases (92.85%) were T-LGL type, and one case belonged to NK-LGL type (7.14%). Anemia was the most common presentation (92.85% of cases), followed by lymphocytosis (85.71% of cases) and neutropenia (78.57% of cases). Four patients (28.57%) presented with thrombocytopenia, and two patients presented with pancytopenia (14.28%). Splenomegaly was seen in two patients (14.28%), and lymphadenopathy in one patient (7.14%). One patient (7.14%) had rheumatoid arthritis, and one (7.14%) had recurrent chest infections. Out of the 14 cases, 5 (35.71%) attained complete remission, 5 (35.71%) attained partial remission, 2 patients were resistant to first-line treatment, and 2 patients were closely followed with observation only. The overall treatment response rate was 83.33%. This study highlights the excellent response rates with immunosuppressive therapy in a rare lymphoproliferative disorder.
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CiteScore
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自引率
0.00%
发文量
80
审稿时长
35 weeks
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