多药耐药泵是细菌耐药的基石

Pavel Nazarov, Marina Kuznetsova, Marina Karakozova
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引用次数: 0

摘要

抗生素耐药性是现代医学的一个全球性问题。后抗生素时代开始的一个先兆是开发新抗生素的复杂性和高成本,以及由于细菌迅速发展的耐药性而导致的效率低下。细菌抗抗生素保护的基石是多药耐药泵(MDR),它参与对外源药物的耐药性形成、毒素的输出、细胞稳态的维持、生物膜和持久细胞的形成。MDR泵是细菌非特异性保护的基础,而药物靶点的修饰、药物的失活、靶点的切换或靶点的隔离是它们保护的第二种特异性途径。由此可见,MDR泵对细菌形成的非特异性保护是阻止抗菌物质渗入细胞的屏障,是决定细菌耐药性的主要因素。了解耐多药泵的机制并平衡评估其对总体耐药性和抗生素敏感性的贡献,将严重推迟后抗生素时代的到来,或在可预见的未来防止其到来
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multidrug resistance pumps as a keystone of bacterial resistance
Antibiotic resistance is a global problem of modern medicine. A harbinger of the onset of the post-antibiotic era is the complexity and high cost of developing new antibiotics, as well as their ineffi ciency due to the rapidly developing resistance of bacteria. The cornerstone of bacterial protection against antibiotics are multidrug resistance pumps (MDR), which are involved in the formation of resistance to xenobiotics, the export of toxins, the maintenance of cellular homeostasis, the formation of biofilms and persistent cells. MDR pumps are the basis for the nonspecific protection of bacteria, while modification of the drug target, inactivation of the drug, switching of the target or sequestration of the target is the second, specific line of their protection. Thus, the nonspecific protection of bacteria formed by MDR pumps is a barrier that prevents the penetration of antibacterial substances into the cell, which is the main factor determining the resistance of bacteria. Understanding the mechanisms of MDR pumps and a balanced assessment of their contribution to overall resistance, as well as to antibiotic sensitivity, will either seriously delay the onset of the post-antibiotic era, or prevent its onset in the foreseeable future
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