不同温度下磷酸可待因在N -甲基-2-吡咯烷酮+ 1-丙醇混合物中的溶解度

IF 1.2 4区 化学 Q4 CHEMISTRY, PHYSICAL
Homa Rezaei, Elaheh Rahimpour, Fleming Martinez, Hongkun Zhao, Abolghasem Jouyban
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引用次数: 0

摘要

摘要本文研究了磷酸可待因在n -甲基-2-吡咯烷酮和1-丙醇混合物中在293.2 ~ 313.2 K常压下的溶解度和热力学性质。溶解度与温度和n -甲基-2-吡咯烷酮比呈正相关。利用数学模型对实测数据进行关联,并通过计算反算值的平均相对偏差来研究其可靠性。还测量了磷酸可待因饱和溶液的密度值,并使用Jouyban-Acree模型进行了关联。此外,还根据Gibbs和van 't Hoff方程计算了磷酸可待因溶解的表观热力学性质(如标准焓、熵和吉布斯自由能)。本研究方案由伊朗大不里士(Tabriz)医科大学药学院学生研究委员会批准并支持,批准号67275。披露声明作者未报告潜在的利益冲突。这项工作得到了大不里士医科大学学生研究委员会的支持[67275]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Solubility of codeine phosphate in N -methyl-2-pyrrolidone + 1-propanol mixtures at different temperatures
ABSTRACTThe purpose of the current study is the investigation of the solubility data and thermodynamic properties of codeine phosphate in mixtures of N-methyl-2-pyrrolidone and 1-propanol under atmospheric pressure at 293.2–313.2 K. Positive correlations of the solubility with temperature and N-methyl-2-pyrrolidone ratio were observed. The measured data were correlated using some mathematical models, and their reliability was studied by computing the mean relative deviations of the back-calculated values. The density values of codeine phosphate saturated solutions were also measured and correlated using the Jouyban–Acree model. Furthermore, the apparent thermodynamic properties of the codeine phosphate solubilisation (e.g. standard enthalpy, entropy, and Gibbs free energy) are also computed based on Gibbs and van’t Hoff equations and reported.KEYWORDS: Codeine phosphatesolubilityN-methyl-2-pyrrolidone1-propanolbinary solvent mixturecosolvency models AcknowledgmentsThe research protocol was approved and supported by the Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran, under grant number 67275.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThe work was supported by the Student Research Committee, Tabriz University of Medical Sciences [67275].
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来源期刊
Physics and Chemistry of Liquids
Physics and Chemistry of Liquids 化学-物理:凝聚态物理
CiteScore
3.30
自引率
8.30%
发文量
43
审稿时长
6-12 weeks
期刊介绍: Physics and Chemistry of Liquids publishes experimental and theoretical papers, letters and reviews aimed at furthering the understanding of the liquid state. The coverage embraces the whole spectrum of liquids, from simple monatomic liquids and their mixtures, through charged liquids (e.g. ionic melts, liquid metals and their alloys, ions in aqueous solution, and metal-electrolyte systems) to molecular liquids of all kinds. It also covers quantum fluids and superfluids, such as Fermi and non-Fermi liquids, superconductors, Bose-Einstein condensates, correlated electron or spin assemblies. By publishing papers on physical aspects of the liquid state as well as those with a mainly chemical focus, Physics and Chemistry of Liquids provides a medium for the publication of interdisciplinary papers on liquids serving its broad international readership of physicists and chemists.
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