级联双亲核取代法合成哌嗪-2-酮衍生物

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2023-10-31 DOI:10.1055/a-2201-9951

Milos Petkovic, Dusica Kusljevic, Milos Jovanovic, Predrag Jovanovic, Gordana Tasic, Milena Simic, Vladimir Savic

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引用次数: 0

摘要

级联，金属促进转化利用氯丙烯酰胺，伯胺和芳基碘提供了良好的产量哌嗪酮。在优化条件下，级联是一锅过程，允许形成三个键。该合成路线由涉及的几个过程的反应速率控制，引入了两点多样性，非常适合组合合成或相关技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution

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Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution

A cascade, metal promoted transformations utilizing chloro allenylamide, primary amine and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as one-pot process allowing formation of three bonds. The synthetic route, controlled by the reaction rates of several processes involved, introduces two points of diversity and is well suited for combinatorial synthesis or related technologies.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.