糖尿病母亲新生儿先天性皮肤发育不全1例报告及文献复习

IF 0.3 Q4 PEDIATRICS
Hajar Pasha, Alireza Yahyaei Shahandashti, Fatemeh Haghshenas, Amir Bahari Bandari
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引用次数: 0

摘要

背景:先天性皮肤发育不全(ACC)是一种罕见的疾病,被认为是新生儿先天缺乏表皮、真皮,在某些情况下,皮下组织。致病机制尚不清楚,尽管这种情况被描述为子宫内皮肤发育中断或变性的结果。胎儿乳头状瘤(FP)时可观察到ACC。病例介绍:我们报告一例8小时大的新生儿女性,出生时双侧对称分布,星状型截骨ACC。她是双胞胎中幸存的一个,另一个胎儿在妊娠13周以上死亡。这种情况描述了ACC伴FP。体格检查显示其他方面正常,没有其他先天性异常。新生儿给予抗菌药膏和抗生素治疗,病变在5天内自行消退,留下疤痕。结论:本报告解释了1例新生儿V型皮肤发育不全先天性畸形,该新生儿在产前病史和临床特征的基础上被批准检测。结果显示,局部和全身抗生素和生理盐水清洗可能是ACC病变愈合的有效治疗方法。3个月后随访,皮肤病变完全愈合,留下很小的萎缩性瘢痕,无需进一步的病变处理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aplasia Cutis Congenita in a Newborn of Diabetic Mother: A Case Report and Review of Literature
Background: Aplasia cutis congenita (ACC) is a rare condition regarded as a congenital absence of the epidermis, dermis, and in some cases, subcutaneous tissues in the newborn. The pathogenic mechanism is unclear, although the condition has been described as a result of the disrupted development or degeneration of skin in utero. ACC may be observed with fetus papyraceous (FP). Case Presentation: We report a case of an 8-hour-old newborn female with bilateral symmetrically distributed, stellate type of truncal ACC at birth. She was the survivor twin as the other fetus died at 13wk+3d gestation. This condition describes ACC with FP. Physical examination showed otherwise normal and managed with no other congenital abnormalities. The newborn was treated with antibacterial ointment and antibiotics, and lesions resolved spontaneously within 5 days, leaving scars. Conclusions: This report explained a newborn with type V cutis aplasia congentia in whom the detection was approved based on the revision of antenatal history and clinical features. The protocol outcome revealed that the topical and systemic antibiotic and washing with normal saline could be an effective treatment for the healing of ACC lesions. Follow-up after 3 months indicated that the skin lesion completely healed, leaving a very small atrophic scar, and no further lesion management was required.
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