{"title":"物种特异性药物前列腺素对新生大肠杆菌病仔猪il-1基因表达水平的影响","authors":"V.V. Strebkova, M.Yu. Syromyatnikov, N.V. Pasko, N.A. Khokhlova, N.A. Strelnikov, E.V. Mikhaylov","doi":"10.52368/2078-0109-2023-59-2-60-65","DOIUrl":null,"url":null,"abstract":"The article presents the data on the expression level of the pro-inflammatory cytokine interleukin-1 (IL-1) in piglets 3-5 days of age diseased with colibacteriosis, against the background of the use of the species-specific drug Prostimul, containing recombinant type 1 cytokine, vitamins A, E and C, in comparison with antibacterial drug Quinocol Plus. The analysis of the obtained data has shown that the drug Prostimul suppresses the expression of IL-1β by 70 times, and Quinocol Plus – by 6.5 times. This fact indicates the prospect of using the drug to reduce the development of an inflammatory reaction in case of colibacteriosis in newborn piglets. When analyzing hematological blood indicators, a decrease in the number of stab neutrophils was revealed against the background of the use of Prostimul and Quinocol Plus. The analysis of leukocyte indices of blood intoxication has indicated that against the background of the use of the drug Prostimul this indicator decreases by 4.9 times, and Quinocol Plus – by 5.6 times, respectively.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EFFECT OF THE SPECIES-SPECIFIC DRUG PROSTIMUL ON THE LEVEL OF IL-1 GENE EXPRESSION IN NEWBORN PIGLETS WITH COLIBACTERIOSIS\",\"authors\":\"V.V. Strebkova, M.Yu. Syromyatnikov, N.V. Pasko, N.A. Khokhlova, N.A. Strelnikov, E.V. Mikhaylov\",\"doi\":\"10.52368/2078-0109-2023-59-2-60-65\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The article presents the data on the expression level of the pro-inflammatory cytokine interleukin-1 (IL-1) in piglets 3-5 days of age diseased with colibacteriosis, against the background of the use of the species-specific drug Prostimul, containing recombinant type 1 cytokine, vitamins A, E and C, in comparison with antibacterial drug Quinocol Plus. The analysis of the obtained data has shown that the drug Prostimul suppresses the expression of IL-1β by 70 times, and Quinocol Plus – by 6.5 times. This fact indicates the prospect of using the drug to reduce the development of an inflammatory reaction in case of colibacteriosis in newborn piglets. When analyzing hematological blood indicators, a decrease in the number of stab neutrophils was revealed against the background of the use of Prostimul and Quinocol Plus. The analysis of leukocyte indices of blood intoxication has indicated that against the background of the use of the drug Prostimul this indicator decreases by 4.9 times, and Quinocol Plus – by 5.6 times, respectively.\",\"PeriodicalId\":477320,\"journal\":{\"name\":\"Učenye zapiski učreždeniâ obrazovaniâ \\\"Vitebskaâ orderna \\\"Znak početa\\\" gosudarstvennaâ akademiâ veterinarnoj mediciny\\\"\",\"volume\":\"25 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Učenye zapiski učreždeniâ obrazovaniâ \\\"Vitebskaâ orderna \\\"Znak početa\\\" gosudarstvennaâ akademiâ veterinarnoj mediciny\\\"\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52368/2078-0109-2023-59-2-60-65\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52368/2078-0109-2023-59-2-60-65","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本文报道了在使用含有重组1型细胞因子和维生素A、E、C的物种特异性药物prostimull的情况下，3-5日龄大肠杆菌病仔猪中促炎细胞因子白细胞介素-1 (IL-1)的表达水平，并与抗菌药物喹诺醇Plus进行了比较。结果表明，prostimulus对IL-1β表达的抑制作用为70倍，对Quinocol Plus -的抑制作用为6.5倍。这一事实表明，在新生仔猪大肠杆菌病的情况下，使用该药物减少炎症反应的发展前景。在分析血液学血液指标时，在使用prostil和Quinocol Plus的背景下，发现刺伤中性粒细胞数量减少。血液中毒白细胞指标分析表明，在使用prostil药物的背景下，该指标分别下降了4.9倍和5.6倍。
EFFECT OF THE SPECIES-SPECIFIC DRUG PROSTIMUL ON THE LEVEL OF IL-1 GENE EXPRESSION IN NEWBORN PIGLETS WITH COLIBACTERIOSIS
The article presents the data on the expression level of the pro-inflammatory cytokine interleukin-1 (IL-1) in piglets 3-5 days of age diseased with colibacteriosis, against the background of the use of the species-specific drug Prostimul, containing recombinant type 1 cytokine, vitamins A, E and C, in comparison with antibacterial drug Quinocol Plus. The analysis of the obtained data has shown that the drug Prostimul suppresses the expression of IL-1β by 70 times, and Quinocol Plus – by 6.5 times. This fact indicates the prospect of using the drug to reduce the development of an inflammatory reaction in case of colibacteriosis in newborn piglets. When analyzing hematological blood indicators, a decrease in the number of stab neutrophils was revealed against the background of the use of Prostimul and Quinocol Plus. The analysis of leukocyte indices of blood intoxication has indicated that against the background of the use of the drug Prostimul this indicator decreases by 4.9 times, and Quinocol Plus – by 5.6 times, respectively.
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