LASER INDUCED CONFORMATIONAL CHANGES OF LIPIDS WITHIN MULTILAMELLAR VESICLES

"The biomedical potential of destabilizing liposomes through photoinduction relies on the use of near-infrared light, which offers inherent therapeutic advantages. Researchers have explored the effects of infrared laser light on dipalmitoyl phosphatidylcholine (DPPC) multilamellar vesicles, specifically investigating the interaction between the laser and zwitterionic dipalmitoyl phosphatidylcholine multilamellar vesicles using Fourier transform infrared spectroscopy and differential scanning calorimetry measurements. The results revealed that laser irradiation increased the number of gauche conformers and led to conformational changes within the acyl chains of the phospholipids. The transition temperature of lyophilized vesicles was also shifted to a lower temperature after laser irradiation, indicating that the laser had a dipalmitoyl phosphatidylcholine multilamellar significant effect on the acyl chains in the dipalmitoyl phosphatidylcholine bilayers and decreased the transition cooperativity of lipid acyl chains. These findings could aid in the development of more effective liposomal drug delivery systems by enhancing our understanding of the interaction between laser and lipid bilayers."