慢性阻塞性肺疾病伴下肢动脉闭塞性动脉粥样硬化频繁加重的临床和免疫学特征

S. N. Kotlyarov, I. A. Suchkov, O. M. Uryasev
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引用次数: 0

摘要

慢性阻塞性肺疾病(COPD)常与动脉粥样硬化性心血管疾病(ASCVD)相关,其中下肢动脉闭塞性动脉粥样硬化或外周动脉疾病(PAD)是重要组成部分。本研究的目的是评估COPD合并PAD频繁加重表型的临床、功能和免疫学特征。材料和方法。共纳入四组COPD患者:20例COPD不常发作且无ASCVD, 20例COPD常发作且无ASCVD, 20例COPD常发作且有PAD, 20例COPD常发作且有PAD表型。分析了20名健康对照者的数据进行比较。评估临床和肺活量数据。分析一般临床实验室数据及呼出液(EBC)和血清中的免疫标志物(白细胞介素1 β (il - 1b)和肿瘤坏死因子(TNF))。结果。与无ASCVD的COPD患者(p < 0.05)和健康对照组(p < 0.001)相比,COPD和PAD患者的EBC和血清中il - 1b和TNF水平较高。COPD的高患病率加剧了无ASCVD和伴发PAD的疾病严重程度的临床和免疫学特征。结论。具有频繁加重和PAD表型的COPD的特点是局部和全身炎症更严重,这与EBC和血清中炎症标志物的增加相对应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical and immunological characteristics of chronic obstructive pulmonary disease with frequent exacerbations associated with obliterating atherosclerosis of lower limb arteries
Chronic obstructive pulmonary disease (COPD) is often associated with atherosclerotic cardiovascular disease (ASCVD), of which obliterating atherosclerosis of lower limb arteries or peripheral arterial disease (PAD) is an important component. The aim of the study was to evaluate the clinical, functional and immunological characteristics of COPD with the phenotype of frequent exacerbations in combination with PAD. Materials and methods. Four groups of COPD patients were included: 20 COPD patients with infrequent exacerbations without ASCVD, 20 COPD patients with frequent exacerbations without ASCVD, 20 patients with frequent exacerbations and PAD, and 20 COPD patients with a phenotype of frequent exacerbations and PAD. Data from 20 healthy controls were analysed for comparison. Clinical and spirometric data were evaluated. General clinical laboratory data and immunological markers (interleukin 1 beta (IL1b) and tumor necrosis factor (TNF) in exhaled breath condensate (EBC) and serum were analysed. Results. Higher levels of IL1b and TNF in EBC and serum were found in patients with COPD and PAD compared to COPD patients without ASCVD (p<0.05) and healthy controls (p<0.001). The high prevalence of COPD exacerbates the clinical and immunological characteristics of disease severity both without ASCVD and with concomitant PAD. Conclusions. COPD with the phenotype of frequent exacerbations and PAD is characterized by greater severity of local and systemic inflammation, which corresponds to increased inflammatory markers in EBC and serum.
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