{"title":"4生长激素缺乏症的治疗","authors":"M.B. Ranke, J.R. Bierich","doi":"10.1016/S0300-595X(86)80008-1","DOIUrl":null,"url":null,"abstract":"<div><p>According to the results reported in the literature and from our own experience, the following recommendations for the treatment of children with GHD can be given:</p><ul><li><span>1.</span><span><p>In order to start GH replacement therapy in early childhood the diagnosis of GHD should be made as early as possible.</p></span></li><li><span>2.</span><span><p>The growth hormone dose during prepubertal age should not fall short of 12 IU/m<sup>2</sup> per week. During spontaneous or induced puberty, the dose needs to be increased, possibly by a factor of two. Daily subcutaneous injections appear most suitable. Treatment with growth hormone releasing factors in cases with hypothalamic GHD, although a promising alternative to the treatment with hGH (<span>Thorner et al, 1985</span>), must be considered experimental at this point.</p></span></li><li><span>3.</span><span><p>Thyroxine replacement at a daily dose of 75–100 μg/m<sup>2</sup> should be given in cases of secondary hypothyroidism.</p></span></li><li><span>4.</span><span><p>Glucocorticoid replacement, if required, should be given at low doses (e.g. hydrocortisone 10 (to 15) mg/m<sup>2</sup> per day in divided doses).</p></span></li><li><span>5.</span><span><p>In cases with additional gonadotropin deficiency, sex steroids (or anabolic steroids) should be given with frequent monitoring of bone maturity not before the age of 13 in girls or 15 years in boys. In boys depot testosterone starting at low doses (e.g. 50–100 mg/month i.m.) will induce a puberty-like increment in height velocity. Since the effect of oestrogens—even in low doses—on growth is uncertain, their administration before achievement of near-normal adult height should be avoided.</p></span></li></ul><p>With the advancement of diagnostic techniques and with the experience in treatment accumulated over the past 25 years, patients with GHD need no longer become dwarfs.</p></div>","PeriodicalId":10454,"journal":{"name":"Clinics in Endocrinology and Metabolism","volume":"15 3","pages":"Pages 495-510"},"PeriodicalIF":0.0000,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-595X(86)80008-1","citationCount":"20","resultStr":"{\"title\":\"4 Treatment of growth hormone deficiency\",\"authors\":\"M.B. Ranke, J.R. 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Treatment with growth hormone releasing factors in cases with hypothalamic GHD, although a promising alternative to the treatment with hGH (<span>Thorner et al, 1985</span>), must be considered experimental at this point.</p></span></li><li><span>3.</span><span><p>Thyroxine replacement at a daily dose of 75–100 μg/m<sup>2</sup> should be given in cases of secondary hypothyroidism.</p></span></li><li><span>4.</span><span><p>Glucocorticoid replacement, if required, should be given at low doses (e.g. hydrocortisone 10 (to 15) mg/m<sup>2</sup> per day in divided doses).</p></span></li><li><span>5.</span><span><p>In cases with additional gonadotropin deficiency, sex steroids (or anabolic steroids) should be given with frequent monitoring of bone maturity not before the age of 13 in girls or 15 years in boys. In boys depot testosterone starting at low doses (e.g. 50–100 mg/month i.m.) will induce a puberty-like increment in height velocity. Since the effect of oestrogens—even in low doses—on growth is uncertain, their administration before achievement of near-normal adult height should be avoided.</p></span></li></ul><p>With the advancement of diagnostic techniques and with the experience in treatment accumulated over the past 25 years, patients with GHD need no longer become dwarfs.</p></div>\",\"PeriodicalId\":10454,\"journal\":{\"name\":\"Clinics in Endocrinology and Metabolism\",\"volume\":\"15 3\",\"pages\":\"Pages 495-510\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1986-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0300-595X(86)80008-1\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinics in Endocrinology and Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0300595X86800081\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinics in Endocrinology and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300595X86800081","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 20
摘要
根据文献报道的结果和我们自己的经验,可以给出以下治疗儿童GHD的建议:1。为了在儿童早期开始生长激素替代治疗,应尽早诊断出GHD。青春期前的生长激素剂量不应低于12 IU/m2 /周。在自发或诱导的青春期,剂量需要增加,可能是两倍。每日皮下注射似乎是最合适的。在下丘脑GHD病例中使用生长激素释放因子治疗,虽然是一种有希望的替代hGH治疗方法(Thorner et al, 1985),但在这一点上必须被认为是实验性的。继发性甲状腺功能减退患者应给予75-100 μg/m2日剂量的甲状腺素替代。如有需要,应以低剂量替代糖皮质激素(如氢化可的松10(至15)mg/m2 /天,分次给药)。在有促性腺激素缺乏症的情况下,应给予性类固醇(或合成代谢类固醇),并经常监测骨骼成熟度,女孩不早于13岁,男孩不早于15岁。在男孩中,低剂量的睾酮(例如50-100毫克/月静脉注射)会引起青春期样的身高速度增长。由于雌激素(即使是低剂量)对生长的影响是不确定的,因此在达到接近正常成人身高之前应避免使用雌激素。随着诊断技术的进步和过去25年积累的治疗经验,GHD患者不再需要变成侏儒。
According to the results reported in the literature and from our own experience, the following recommendations for the treatment of children with GHD can be given:
1.
In order to start GH replacement therapy in early childhood the diagnosis of GHD should be made as early as possible.
2.
The growth hormone dose during prepubertal age should not fall short of 12 IU/m2 per week. During spontaneous or induced puberty, the dose needs to be increased, possibly by a factor of two. Daily subcutaneous injections appear most suitable. Treatment with growth hormone releasing factors in cases with hypothalamic GHD, although a promising alternative to the treatment with hGH (Thorner et al, 1985), must be considered experimental at this point.
3.
Thyroxine replacement at a daily dose of 75–100 μg/m2 should be given in cases of secondary hypothyroidism.
4.
Glucocorticoid replacement, if required, should be given at low doses (e.g. hydrocortisone 10 (to 15) mg/m2 per day in divided doses).
5.
In cases with additional gonadotropin deficiency, sex steroids (or anabolic steroids) should be given with frequent monitoring of bone maturity not before the age of 13 in girls or 15 years in boys. In boys depot testosterone starting at low doses (e.g. 50–100 mg/month i.m.) will induce a puberty-like increment in height velocity. Since the effect of oestrogens—even in low doses—on growth is uncertain, their administration before achievement of near-normal adult height should be avoided.
With the advancement of diagnostic techniques and with the experience in treatment accumulated over the past 25 years, patients with GHD need no longer become dwarfs.