桔梗素D通过调节eif4e介导的RNA甲基组抑制非小细胞肺癌血管生成的血管模拟

IF 6.1 1区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Analysis Pub Date : 2023-10-01 DOI:10.1016/j.jpha.2023.10.003

Shuyu Zheng, Yanlin Xin, Jiamin Lin, Zejuan Xie, Keyu Cheng, Shanshan Wang, Wenli Lu, Hao Yang, Tianming Lu, Jun Li, Ruogu Qi, Yuanyuan Guo

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引用次数: 0

摘要

•通过PD全转录组测序和RIP验证鉴定m7G-lncRNAs。•在体内和体外研究PD对NSCLC的抗vm作用。联合使用PD和eIF4E抑制剂通过破坏EGFR的稳定性来治疗NSCLC，发现了协同效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome

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Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome

• The m7G-lncRNAs were identified through whole transcriptome-seq of PD and RIP validation. • The anti-VM effect of PD on NSCLC was investigated both in vivo and in vitro. • The synergistic effect was found in combinational use of PD and eIF4E inhibitor on NSCLC via destabilization of EGFR.

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来源期刊

Journal of Pharmaceutical Analysis Chemistry-Electrochemistry

CiteScore

16.20

自引率

2.30%

发文量

674

审稿时长

22 weeks

期刊介绍： The Journal of Pharmaceutical Analysis (JPA), established in 2011, serves as the official publication of Xi'an Jiaotong University. JPA is a monthly, peer-reviewed, open-access journal dedicated to disseminating noteworthy original research articles, review papers, short communications, news, research highlights, and editorials in the realm of Pharmacy Analysis. Encompassing a wide spectrum of topics, including Pharmaceutical Analysis, Analytical Techniques and Methods, Pharmacology, Metabolism, Drug Delivery, Cellular Imaging & Analysis, Natural Products, and Biosensing, JPA provides a comprehensive platform for scholarly discourse and innovation in the field.