microrna在肥胖中的作用:强调与慢性肾脏疾病和心血管疾病的联系

Obesities Pub Date : 2023-09-13 DOI:10.3390/obesities3030020
Valérie Metzinger-Le Meuth, Laurent Metzinger
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引用次数: 0

摘要

肥胖已经成为一种全球性的流行病,导致了许多慢性疾病的发展,包括糖尿病、慢性肾病(CKD)和心血管疾病。MicroRNAs (miRNAs)已成为多种生物过程的关键调节因子,包括代谢、炎症和组织重塑,使其成为肥胖相关病理的关键参与者。这篇综述旨在全面了解mirna在肥胖中的作用,特别强调它们在CKD和心血管疾病发病机制中的作用。我们强调了特定的mirna参与脂肪组织发育、能量稳态、炎症和胰岛素抵抗,有助于肥胖的发病机制。此外,我们探索了mirna对肾脏纤维化和炎症的影响,为它们在CKD发生和进展中的作用提供了线索。此外,我们讨论了mirna对内皮功能障碍、动脉粥样硬化和心脏重塑的影响,强调了它们在肥胖相关心血管疾病中的作用。了解mirna在这些相互关联的条件下的调节功能,有望改善诊断、预后和治疗干预。事实上,mirna是肥胖相关疾病的潜在诊断生物标志物,尽管在其临床转化之前仍有挑战有待阐明。此外,我们强调了靶向mirna作为治疗干预措施的新兴策略,以减轻肥胖对肾脏和心血管健康的有害影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Roles of MicroRNAs in Obesity: Emphasizing Links with Chronic Kidney Disease and Cardiovascular Disorders
Obesity has become a global epidemic, contributing to the development of numerous chronic diseases, including diabetes, chronic kidney disease (CKD) and cardiovascular disorders. MicroRNAs (miRNAs) have emerged as key regulators in various biological processes, including metabolism, inflammation, and tissue remodeling, making them pivotal players in obesity-related pathologies. This review aims to provide comprehensive insights into the roles of miRNAs in obesity, with a particular emphasis on their involvement in the pathogenesis of CKD and cardiovascular disorders. We highlight the involvement of specific miRNAs in adipose tissue development, energy homeostasis, inflammation, and insulin resistance, contributing to the pathogenesis of obesity. Moreover, we explore the impact of miRNAs on renal fibrosis and inflammation, giving clues on their roles in the development and progression of CKD. Additionally, we discuss the influence of miRNAs on endothelial dysfunction, atherosclerosis, and cardiac remodeling, emphasizing their contribution to obesity-related cardiovascular disorders. Understanding the regulatory functions of miRNAs in these interconnected conditions holds promise for improved diagnosis, prognosis, and therapeutic interventions. Indeed, miRNAs are potential diagnostic biomarkers for obesity-related diseases, although challenges remain to be elucidated before their clinical translation. Furthermore, we highlight the emerging strategies that target miRNAs as therapeutic interventions to mitigate the detrimental effects of obesity on kidney and cardiovascular health.
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