{"title":"甲状腺功能低下患者CTLA4基因多态性与甲状腺功能检测的关系","authors":"None Shahad Tareq Rradeef, None Elham Abed Mahdi","doi":"10.36329/jkcm/2023/v2.i10.13409","DOIUrl":null,"url":null,"abstract":"Objective: To recognize the role of Cytotoxic T-Lymphocyte Antigen 4 CTLA4 gene polymorphism (rs231775A/G) in Hashimoto's thyroiditis (HT) patients and a study its correlation with other clinical data.Design and MethodsCase-control research was conducted on 200 females, with 100 patients with Hashimoto's thyroiditis aged 18-68 years and 100 age and gender-matched healthy volunteers. Patients were drawn from Al-Sadder Medical City in Al-Najaf Governorate. All participants underwent to medical examinations to ensure they were suffering from Hashimoto's thyroiditis. The Real-time-PCR method was used to analyze the genotyping of the CTLA4 gene, and the levels of T3, T4, TSH, Anti-TPO, and Anti-TG were assessed using an ELISA kit in all study groups","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"119 5","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genetic polymorphism of CTLA4 with functional thyroid tests in hypothyroid disease patients\",\"authors\":\"None Shahad Tareq Rradeef, None Elham Abed Mahdi\",\"doi\":\"10.36329/jkcm/2023/v2.i10.13409\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To recognize the role of Cytotoxic T-Lymphocyte Antigen 4 CTLA4 gene polymorphism (rs231775A/G) in Hashimoto's thyroiditis (HT) patients and a study its correlation with other clinical data.Design and MethodsCase-control research was conducted on 200 females, with 100 patients with Hashimoto's thyroiditis aged 18-68 years and 100 age and gender-matched healthy volunteers. Patients were drawn from Al-Sadder Medical City in Al-Najaf Governorate. All participants underwent to medical examinations to ensure they were suffering from Hashimoto's thyroiditis. The Real-time-PCR method was used to analyze the genotyping of the CTLA4 gene, and the levels of T3, T4, TSH, Anti-TPO, and Anti-TG were assessed using an ELISA kit in all study groups\",\"PeriodicalId\":489104,\"journal\":{\"name\":\"Journal of Kufa for Chemical Sciences\",\"volume\":\"119 5\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Kufa for Chemical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36329/jkcm/2023/v2.i10.13409\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Kufa for Chemical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36329/jkcm/2023/v2.i10.13409","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Genetic polymorphism of CTLA4 with functional thyroid tests in hypothyroid disease patients
Objective: To recognize the role of Cytotoxic T-Lymphocyte Antigen 4 CTLA4 gene polymorphism (rs231775A/G) in Hashimoto's thyroiditis (HT) patients and a study its correlation with other clinical data.Design and MethodsCase-control research was conducted on 200 females, with 100 patients with Hashimoto's thyroiditis aged 18-68 years and 100 age and gender-matched healthy volunteers. Patients were drawn from Al-Sadder Medical City in Al-Najaf Governorate. All participants underwent to medical examinations to ensure they were suffering from Hashimoto's thyroiditis. The Real-time-PCR method was used to analyze the genotyping of the CTLA4 gene, and the levels of T3, T4, TSH, Anti-TPO, and Anti-TG were assessed using an ELISA kit in all study groups
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