{"title":"微波辅助合成五元和七元杂环及其生物活性研究","authors":"None Samah Hassan Hadi, None Faez A. Alrammahi","doi":"10.36329/jkcm/2023/v2.i10.13553","DOIUrl":null,"url":null,"abstract":"In this study, we synthesized one azo compound (S19) and then condensat this compound with a carbonyl compound to give a Schiff base (S20) as the key step. The next step Schiff base reacted with some Amino acids and Anhydrides by cycloaddition reaction to give five-membered (S22, S23) and seven-membered (S21, S24) heterocyclic compounds. The chemical Structure for of the synthesized compounds were confirmed by using spectroscopic techniques (IR and NMR). In addition, tested their biological activity against Staphylococcus Aureus and Escherichia Coli displayed good activity.","PeriodicalId":489104,"journal":{"name":"Journal of Kufa for Chemical Sciences","volume":"3 4","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microwave-Assisted Synthesis of Five and Seven-Membered Heterocycles and Study Their Biological Activity\",\"authors\":\"None Samah Hassan Hadi, None Faez A. Alrammahi\",\"doi\":\"10.36329/jkcm/2023/v2.i10.13553\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, we synthesized one azo compound (S19) and then condensat this compound with a carbonyl compound to give a Schiff base (S20) as the key step. The next step Schiff base reacted with some Amino acids and Anhydrides by cycloaddition reaction to give five-membered (S22, S23) and seven-membered (S21, S24) heterocyclic compounds. The chemical Structure for of the synthesized compounds were confirmed by using spectroscopic techniques (IR and NMR). In addition, tested their biological activity against Staphylococcus Aureus and Escherichia Coli displayed good activity.\",\"PeriodicalId\":489104,\"journal\":{\"name\":\"Journal of Kufa for Chemical Sciences\",\"volume\":\"3 4\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Kufa for Chemical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36329/jkcm/2023/v2.i10.13553\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Kufa for Chemical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36329/jkcm/2023/v2.i10.13553","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Microwave-Assisted Synthesis of Five and Seven-Membered Heterocycles and Study Their Biological Activity
In this study, we synthesized one azo compound (S19) and then condensat this compound with a carbonyl compound to give a Schiff base (S20) as the key step. The next step Schiff base reacted with some Amino acids and Anhydrides by cycloaddition reaction to give five-membered (S22, S23) and seven-membered (S21, S24) heterocyclic compounds. The chemical Structure for of the synthesized compounds were confirmed by using spectroscopic techniques (IR and NMR). In addition, tested their biological activity against Staphylococcus Aureus and Escherichia Coli displayed good activity.
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