EEG features in patients with different subtypes of prolonged and chronic endogenous manic-delusional states

The purpose of the study . Analysis of the features of EEG spectral parameters in patients with polymorphic and monomorphic subtypes of prolonged and chronic endogenous manic-delusional states (PEMDS). Materials and methods . A clinical-neurophysiological study was carried out in 76 female patients with monomorphic (group 1, 34 patients) and polymorphic (group 2, 42 patients) subtypes of PEMDS, identified based on clinical-dynamic analysis. Results . In the group 1, compared with the group 2, there were significantly lower values of the spectral power of the pre-treatment EEG in most EEG leads and frequency sub-bands, which reflect a significant deficit in the brain inhibitory systems. In the group 2, the EEG slowdown (in the delta-frequency sub-band) after treatment course, was significantly more pronounced in the frontal-anterotemporal-central cortical zones of the left hemisphere, reflecting a greater increase of the neurophysiological processes of inhibition in these brain areas under the influence of treatment, which leads to an improvement in the clinical condition of patients. Conclusions . The revealed differences in the brain functional activity organization may mediate the features of the clinical picture and therapeutic response in patients with polymorphic and monomorphic subtypes of PEMDS.