肝细胞球囊是由于高度明显的糖原病，可能与脂肪变性和代谢重编程有关

IF 3.1 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Clinical and Translational Hepatology Pub Date : 2023-10-19 DOI:10.14218/jcth.2023.00242

Silvia Ribback, Kristin Peters, Mohd Yasser, Jessica Prey, Paula Wilhelmi, Qin Su, Frank Dombrowski, Peter Bannasch

{"title":"肝细胞球囊是由于高度明显的糖原病，可能与脂肪变性和代谢重编程有关","authors":"Silvia Ribback, Kristin Peters, Mohd Yasser, Jessica Prey, Paula Wilhelmi, Qin Su, Frank Dombrowski, Peter Bannasch","doi":"10.14218/jcth.2023.00242","DOIUrl":null,"url":null,"abstract":"Background and AimsHepatocellular ballooning is a common finding in chronic liver disease, mainly characterized by rarefied cytoplasm that often contains Mallory-Denk bodies (MDB). Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic human liver diseases prompts the question whether ballooned hepatocytes (BH) are damaged cells on the path to death or rather viable cells, possibly involved in neoplastic development.","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"47 1","pages":"0"},"PeriodicalIF":3.1000,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hepatocellular Ballooning is Due to Highly Pronounced Glycogenosis Potentially Associated with Steatosis and Metabolic Reprogramming\",\"authors\":\"Silvia Ribback, Kristin Peters, Mohd Yasser, Jessica Prey, Paula Wilhelmi, Qin Su, Frank Dombrowski, Peter Bannasch\",\"doi\":\"10.14218/jcth.2023.00242\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and AimsHepatocellular ballooning is a common finding in chronic liver disease, mainly characterized by rarefied cytoplasm that often contains Mallory-Denk bodies (MDB). Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic human liver diseases prompts the question whether ballooned hepatocytes (BH) are damaged cells on the path to death or rather viable cells, possibly involved in neoplastic development.\",\"PeriodicalId\":15484,\"journal\":{\"name\":\"Journal of Clinical and Translational Hepatology\",\"volume\":\"47 1\",\"pages\":\"0\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2023-10-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical and Translational Hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14218/jcth.2023.00242\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical and Translational Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14218/jcth.2023.00242","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景和目的肝细胞球囊是慢性肝病的常见发现，主要表现为细胞质稀薄，常含有Mallory-Denk小体(MDB)。气球化主要归因于变性，但它与动物模型和慢性人类肝脏疾病中肿瘤前肝细胞病变特征的糖原性/脂肪变性变化惊人地相似，这引发了一个问题:气球化肝细胞(BH)是走向死亡的受损细胞，还是可能参与肿瘤发展的活细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Hepatocellular Ballooning is Due to Highly Pronounced Glycogenosis Potentially Associated with Steatosis and Metabolic Reprogramming

Background and AimsHepatocellular ballooning is a common finding in chronic liver disease, mainly characterized by rarefied cytoplasm that often contains Mallory-Denk bodies (MDB). Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic human liver diseases prompts the question whether ballooned hepatocytes (BH) are damaged cells on the path to death or rather viable cells, possibly involved in neoplastic development.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.40

自引率

2.80%

发文量

496