Fabian Kalt , Martin Hüllner , Moritz C. Wurnig , Gregoire B. Morand , Martina A. Broglie , Paul Stolzmann , Martin Lanzer
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Standardized uptake value (SUV), total lesion glycolysis (TLG) and apparent diffusion coefficient (ADC) were measured in pretreatment imaging (FDG-PET/CT, FDG-PET/MR, DWI MR). Statistical analysis was performed using Mann-Whitney-U tests. All p values reported are two-sided, and p values < 0.05 were considered statistically significant.</p></div><div><h3>Results</h3><p>142 patients were included. 67% of tumors were HPV-positive. Mean SUV<sub>max</sub> in FDG-PET was 15.0+/-5.9 for HPV-positive tumors and 18.6+/-9.7 for HPV-negative tumors (p = 0.15). Mean ADC was 1109 x 10<sup>6</sup> mm<sup>2</sup>/s+/-326.8 for HPV-positive tumors and 1045.8 x 10<sup>6</sup> mm<sup>2</sup>/s+/-467.0 for HPV-negative tumors (p = 0.76).</p></div><div><h3>Conclusion</h3><p>and Relevance: We found no correlation between oropharyngeal carcinoma HPV status and any of the analyzed imaging parameters.</p></div>","PeriodicalId":100051,"journal":{"name":"Advances in Oral and Maxillofacial Surgery","volume":"13 ","pages":"Article 100464"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667147623000766/pdfft?md5=99ff6db4030f3fe418e355d9e9209f7d&pid=1-s2.0-S2667147623000766-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Association of oropharyngeal cancer HPV status with diffusion-weighted MR imaging and FDG-PET parameters\",\"authors\":\"Fabian Kalt , Martin Hüllner , Moritz C. Wurnig , Gregoire B. 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Standardized uptake value (SUV), total lesion glycolysis (TLG) and apparent diffusion coefficient (ADC) were measured in pretreatment imaging (FDG-PET/CT, FDG-PET/MR, DWI MR). Statistical analysis was performed using Mann-Whitney-U tests. All p values reported are two-sided, and p values < 0.05 were considered statistically significant.</p></div><div><h3>Results</h3><p>142 patients were included. 67% of tumors were HPV-positive. Mean SUV<sub>max</sub> in FDG-PET was 15.0+/-5.9 for HPV-positive tumors and 18.6+/-9.7 for HPV-negative tumors (p = 0.15). 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引用次数: 0
摘要
背景人乳头瘤病毒（HPV）感染是口咽癌的一个重要危险因素。有几项研究分析了肿瘤 HPV 状态与 FDG-PET/CT 和磁共振（MR）弥散加权成像（DWI）中不同成像参数的关系，但结果相互矛盾。在这项回顾性研究中，我们调查了HPV状态对FDG成像和MR DWI不同参数的影响。方法在这项回顾性单中心研究中，我们分析了2018年1月至2020年12月期间在瑞士一家三级中心确诊的口咽癌患者。HPV状态通过p16免疫组化和/或PCR进行评估。在预处理成像（FDG-PET/CT、FDG-PET/MR、DWI MR）中测量了标准化摄取值（SUV）、病变总糖酵解（TLG）和表观弥散系数（ADC）。统计分析采用 Mann-Whitney-U 检验。所有报告的 p 值均为双侧，p 值为 0.05 时具有统计学意义。67%的肿瘤为HPV阳性。HPV阳性肿瘤的FDG-PET平均SUVmax为15.0+/-5.9，HPV阴性肿瘤为18.6+/-9.7（P = 0.15）。HPV阳性肿瘤的平均ADC为1109 x 106 mm2/s+/-326.8，HPV阴性肿瘤的平均ADC为1045.8 x 106 mm2/s+/-467.0（p = 0.76）：我们没有发现口咽癌 HPV 状态与任何分析的成像参数之间存在相关性。
Association of oropharyngeal cancer HPV status with diffusion-weighted MR imaging and FDG-PET parameters
Background
Human papilloma virus (HPV) infection is an important risk factor in oropharyngeal cancer. Several studies have analyzed the association of tumoral HPV status and different imaging parameters in FDG-PET/CT and magnetic resonance (MR) diffusion-weighted imaging (DWI), with contradictory findings. In this retrospective study, the influence of HPV-status on different parameters in FDG-imaging and MR DWI is investigated.
Methods
In this retrospective, single-center study we analyzed patients diagnosed with oropharyngeal cancer between January 2018 and December 2020 at a tertiary center in Switzerland. HPV status was assessed via p16 immunohistochemistry and/or PCR. Standardized uptake value (SUV), total lesion glycolysis (TLG) and apparent diffusion coefficient (ADC) were measured in pretreatment imaging (FDG-PET/CT, FDG-PET/MR, DWI MR). Statistical analysis was performed using Mann-Whitney-U tests. All p values reported are two-sided, and p values < 0.05 were considered statistically significant.
Results
142 patients were included. 67% of tumors were HPV-positive. Mean SUVmax in FDG-PET was 15.0+/-5.9 for HPV-positive tumors and 18.6+/-9.7 for HPV-negative tumors (p = 0.15). Mean ADC was 1109 x 106 mm2/s+/-326.8 for HPV-positive tumors and 1045.8 x 106 mm2/s+/-467.0 for HPV-negative tumors (p = 0.76).
Conclusion
and Relevance: We found no correlation between oropharyngeal carcinoma HPV status and any of the analyzed imaging parameters.
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