KOH+S与某些抗生素的速率常数用竞争抑制剂法测定

Tatiana Isac-Gutul, Elena Tutovan, Denis Nika
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引用次数: 0

摘要

深度氧化法(AOP)广泛应用于地表水和废水中抗生素和其他微量污染物的降解。AOP对药物的降解程度可以通过羟基自由基与底物的相互作用速率常数KOH+S值以及伴随降解过程的其他物理化学性质来预测,因此这些因素对污水处理工艺方案的设计是重要的。此外,已知koh +S值的底物可以用来评价AOP的适用性和效率,并阐明给定污染物的动力学和降解机制。研究了过氧化氢在蒸馏水中光解过程中N,N-二甲基-对亚硝基苯胺(PNDMA)在UV - H2O2体系中不同污染水(含磺胺类药物-乙酰唑胺(AC)和邻苯二甲基磺胺噻唑(FL)、氟喹尼酮类药物-莫西沙星(MOX)和环丙沙星(CPF)为污染物的水溶液)存在下的氧化速率。药物浓度在2.5 ~ 25mg /L之间变化。采用ДРТ-1000”高压汞灯作为照射源。采用竞争受体法,根据动力学曲线,确定了•OH自由基与上述药物的相互作用常数:kOH+AC = 8.5 ×109 L/mol×s;kOH+FL = 8.5×109 L/mol×s;kOH+MOX = 1.42×109 L/mol×s;kOH+CPF = 6.3×109 L/mol×s和天然水在模型系统自净化过程中的抑制能力Σ ki[Si]。各常数的计算值在(5.4-17.7)×106 s-1之间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The rate constants KOH+S with some antibiotics determination by the competetive inhibitors method
Advanced oxidation processes (AOP) are widely used for the degradation of antibiotics and other micropollutants in surface and waste waters. The degree of degradation of a drug by an AOP can be predicted from the rate constant of the interaction of hydroxyl radicals with the substrate - KOH+S value, as well as from other physicochemical properties accompanying the degradation processes, and therefore these factors are important for the design of technological schemes of treatment of polluted water. Moreover, a substrate withKOH+S value known can be used to evaluate the applicability and efficiency of AOP and elucidate the kinetics and degradation mechanism of the given pollutant. In this work, the rate of the oxidation of N,N-Dimethyl-p-nitrosoaniline (PNDMA) during the photolysis of hydrogen peroxide in distilled water and in the presence of different amounts of polluted water (aqueous solutions containing sulfonamides – acetazolamide (AC) and phthalylsulfathiazole (FL), fluoroquinilones - moxifloxacin (MOX) and ciprofloxacin (CPF) as pollutants) in the UV - H2O2 systems was studied. The concentration of the drugs varied between 2.5 mg/L and 25 mg/L. The ,,ДРТ-1000” high-pressure mercury vapor lamp as the irradiation source was used. Using competitive acceptors method and based on the kinetic curves, the interaction constants of •OH radicals with the mentioned drugs were determined: kOH+AC = 8.5 ×109 L/mol×s; kOH+FL = 8.5×109 L/mol×s; kOH+MOX = 1.42×109 L/mol×s; kOH+CPF = 6.3×109 L/mol×s and the inhibiting capacity of natural waters Σ ki[Si] in the selfpurification process in the model systems used. The calculated values of the respective constants are varies between (5.4-17.7)×106 s-1.
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