针对COVID-19的非特异性医疗保护手段

Q4 Medicine
T. E. Sizikova, E. V. Lebedinskaya, O. V. Chukhralya, A. A. Petrov, V. N. Lebedev, S. V. Borisevich
{"title":"针对COVID-19的非特异性医疗保护手段","authors":"T. E. Sizikova, E. V. Lebedinskaya, O. V. Chukhralya, A. A. Petrov, V. N. Lebedev, S. V. Borisevich","doi":"10.37489/0235-2990-2023-68-5-6-69-76","DOIUrl":null,"url":null,"abstract":"At the beginning of 2020, humanity faced the pandemic of a novel coronavirus infection – COVID-19. The disease has become one of the most contagious for the entire history of mankind. Among medical means of protection, which can be used for prophylactics and treatment of COVID-19, non-specific medical medical protection means play an important role. The aim of this work is to analyze and evaluate the effectiveness of non-specific medical protection means against COVID-19. These medications are divided in two groups in accordance with the targets of their actions. The medications of the first group either block the virus from entering the cell, or inhibit the enzymes involved in viral RNA replication. The other group of medications affects the immune system of a macroorganism, which plays a crucial role in infection resistance, or blocks inflammatory processes in the lungs. Favipiravir is an example of a broad-spectrum antiviral drug with an established activity against SARS-CoV-2 in particular. During the development of new non-specific medical protection means against COVID-19, a comprehensive validation in representative randomized clinical trials is an important condition for their implementation in medical practice.","PeriodicalId":53646,"journal":{"name":"Antibiotiki i Khimioterapiya","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-Specific Means of Medical Protection Against COVID-19\",\"authors\":\"T. E. Sizikova, E. V. Lebedinskaya, O. V. Chukhralya, A. A. Petrov, V. N. Lebedev, S. V. Borisevich\",\"doi\":\"10.37489/0235-2990-2023-68-5-6-69-76\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"At the beginning of 2020, humanity faced the pandemic of a novel coronavirus infection – COVID-19. The disease has become one of the most contagious for the entire history of mankind. Among medical means of protection, which can be used for prophylactics and treatment of COVID-19, non-specific medical medical protection means play an important role. The aim of this work is to analyze and evaluate the effectiveness of non-specific medical protection means against COVID-19. These medications are divided in two groups in accordance with the targets of their actions. The medications of the first group either block the virus from entering the cell, or inhibit the enzymes involved in viral RNA replication. The other group of medications affects the immune system of a macroorganism, which plays a crucial role in infection resistance, or blocks inflammatory processes in the lungs. Favipiravir is an example of a broad-spectrum antiviral drug with an established activity against SARS-CoV-2 in particular. During the development of new non-specific medical protection means against COVID-19, a comprehensive validation in representative randomized clinical trials is an important condition for their implementation in medical practice.\",\"PeriodicalId\":53646,\"journal\":{\"name\":\"Antibiotiki i Khimioterapiya\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Antibiotiki i Khimioterapiya\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37489/0235-2990-2023-68-5-6-69-76\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antibiotiki i Khimioterapiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37489/0235-2990-2023-68-5-6-69-76","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

2020年初,人类面临着新型冠状病毒感染COVID-19的大流行。这种疾病已经成为整个人类历史上最具传染性的疾病之一。在预防和治疗新冠肺炎的医疗防护手段中,非特异性医疗防护手段发挥着重要作用。本研究的目的是分析和评估非特异性医疗防护手段对COVID-19的有效性。这些药物根据其作用目标分为两组。第一组药物要么阻止病毒进入细胞,要么抑制参与病毒RNA复制的酶。另一组药物影响大型生物的免疫系统,它在抵抗感染中起着至关重要的作用,或者阻止肺部的炎症过程。Favipiravir是广谱抗病毒药物的一个例子,特别是对SARS-CoV-2具有确定的活性。在新型非特异性医疗防护手段开发过程中,具有代表性的随机临床试验的全面验证是其在医疗实践中实施的重要条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-Specific Means of Medical Protection Against COVID-19
At the beginning of 2020, humanity faced the pandemic of a novel coronavirus infection – COVID-19. The disease has become one of the most contagious for the entire history of mankind. Among medical means of protection, which can be used for prophylactics and treatment of COVID-19, non-specific medical medical protection means play an important role. The aim of this work is to analyze and evaluate the effectiveness of non-specific medical protection means against COVID-19. These medications are divided in two groups in accordance with the targets of their actions. The medications of the first group either block the virus from entering the cell, or inhibit the enzymes involved in viral RNA replication. The other group of medications affects the immune system of a macroorganism, which plays a crucial role in infection resistance, or blocks inflammatory processes in the lungs. Favipiravir is an example of a broad-spectrum antiviral drug with an established activity against SARS-CoV-2 in particular. During the development of new non-specific medical protection means against COVID-19, a comprehensive validation in representative randomized clinical trials is an important condition for their implementation in medical practice.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Antibiotiki i Khimioterapiya
Antibiotiki i Khimioterapiya Medicine-Infectious Diseases
CiteScore
0.80
自引率
0.00%
发文量
46
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信