{"title":"脑线粒体通透性、过渡孔和复合体I在缺氧反应中的年龄相关性变化","authors":"Odeta Arandarcikaite","doi":"10.26717/bjstr.2023.51.008169","DOIUrl":null,"url":null,"abstract":"The opening of the mitochondrial permeability transition pore (mPTP) is thought to be one of the processes leading to cell death during ischemia, while the regulation of opening of the mPTP during development and aging remain obscure. In this study, we compared the effects of in vitro 90 min hypoxia on mPTP sensitivity to Ca2+ mitochondrial respiration, and infarct zone size in 7 day old, 2-3, 8-10 and 24-26 months old rat brains with a particular focus on mitochondrial respiratory chain complex I.","PeriodicalId":9187,"journal":{"name":"Biomedical Journal of Scientific and Technical Research","volume":"233 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"\\\"Age-Related Variations of the Brain Mitochondrial Permeability Transition Pore and Complex I in Response to Hypoxia\\\"\",\"authors\":\"Odeta Arandarcikaite\",\"doi\":\"10.26717/bjstr.2023.51.008169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The opening of the mitochondrial permeability transition pore (mPTP) is thought to be one of the processes leading to cell death during ischemia, while the regulation of opening of the mPTP during development and aging remain obscure. In this study, we compared the effects of in vitro 90 min hypoxia on mPTP sensitivity to Ca2+ mitochondrial respiration, and infarct zone size in 7 day old, 2-3, 8-10 and 24-26 months old rat brains with a particular focus on mitochondrial respiratory chain complex I.\",\"PeriodicalId\":9187,\"journal\":{\"name\":\"Biomedical Journal of Scientific and Technical Research\",\"volume\":\"233 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Journal of Scientific and Technical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26717/bjstr.2023.51.008169\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Journal of Scientific and Technical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26717/bjstr.2023.51.008169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
"Age-Related Variations of the Brain Mitochondrial Permeability Transition Pore and Complex I in Response to Hypoxia"
The opening of the mitochondrial permeability transition pore (mPTP) is thought to be one of the processes leading to cell death during ischemia, while the regulation of opening of the mPTP during development and aging remain obscure. In this study, we compared the effects of in vitro 90 min hypoxia on mPTP sensitivity to Ca2+ mitochondrial respiration, and infarct zone size in 7 day old, 2-3, 8-10 and 24-26 months old rat brains with a particular focus on mitochondrial respiratory chain complex I.
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