测定阿苯达唑对猩猩STH感染的疗效

Naim Khir, Mehru Nisha, Woei Yenn Tong, Fabian Davamani
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引用次数: 0

摘要

导言:据世卫组织称,来自不卫生和卫生生活方式不当的贫困社区的儿童中,土壤传播的蠕虫(STH)感染可感染高达90%。在西马来西亚,通常土著居民(Orang Asli)容易感染STH感染。阿苯达唑(400毫克)是一种用于治疗STH感染的驱虫药,已有30多年的历史。因此,本项目的主要目的是评估单剂量阿苯达唑(400mg)对猩猩STH感染的疗效。方法:粪便标本采集于马来西亚士门尼的Hulu Langat。他们之前没有接受过驱虫治疗。采用浮法浓缩(标准盐糖溶液),提取阿苯达唑(400mg)处理前后的虫卵量。结果:治疗后1个月共44例。对毛滴虫和蛔虫的治愈率分别为11.6% (n=5)和35.0% (n=14)。此外,阿苯达唑治疗后,两种STHs均未发生严重感染。结论:所选驱虫药治愈率优于毛蛾驱虫药。然而,阿苯达唑处理后,这两个物种的卵量都有所减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Determining the Efficacy of Albendazole Against STH Infection Among Orang Asli
Introduction: According to WHO, soil-transmitted helminth (STH) infections could infect up to 90% of children from deprived communities with unhygiene and improper sanitation lifestyle. In West Malaysia, commonly the aboriginal people (Orang Asli) is prone to be infected with STH infections. Albendazole (400mg) is an anthelminthic drug that has been used for more than 30 years to cure STH infections. Hence, the main objective of this project was to evaluate the efficacy of single-dose albendazole (400mg) against STH infections among Orang Asli. Methods: Stool samples were collected in Hulu Langat, Semenyih, Malaysia. Who had not previously undergone deworming treatment. The parasites were concentrated by floatation technique (using the standard salt-sugar solution) to extract the amount of helminths’ egg before and after the albendazole treatment (400mg). Results: There were 44 participants after one-month post-treatment. The cure rate (CR) for Trichuris trichiura and Ascaris lumbricoides was 11.6% (n=5) and 35.0% (n=14), respectively. Moreover, there was no heavy infection for both STHs during the post-treatment of albendazole. Conclusion: The results indicated that the chosen anthelminthic showed higher cure rate efficacy in A.lumbricoides than T.trichiura. However, both species had decreased egg burden post-treatment with albendazole.
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
28
期刊介绍: The Malaysian Journal of Medicine and Health Sciences (MJMHS) is published by the Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. The main aim of the MJMHS is to be a premier journal on all aspects of medicine and health sciences in Malaysia and internationally. The focus of the MJMHS will be on results of original scientific research and development, emerging issues and policy analyses pertaining to medical, biomedical and clinical sciences.
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