[18F]单组分SABR对乳腺癌骨转移的影响

Nicholas Hardcastle, Yang Liu, Shankar Siva, Steven David
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引用次数: 0

摘要

乳腺癌通常转移到骨骼,立体定向消融体放射治疗(SABR)是一种新兴的治疗低转移性疾病的方法。准确成像骨转移及其对治疗的反应是具有挑战性的。[18 F] nafe - pet在检测乳腺癌骨转移方面比传统骨扫描具有更高的敏感性和特异性。在这项预先定义的前瞻性试验的二次分析中,我们评估了SABR后[18 F]NaF摄取的变化。少转移性乳腺癌患者接受20 Gy的单次放疗,最多可达到三个骨转移灶。[18 F]在SABR前和SABR后12个月获得NaF-PET。将治疗前和治疗后[18 F]的NaF-PET图像注册到治疗计划CT上。量化肿瘤SUV max和SUV mean的相对变化。每个放射治疗等剂量等值线与非肿瘤骨的交点被创建。对接受0-20 Gy剂量的非肿瘤骨亚体积中SUV平均值的变化进行了量化。共有14例患者,17例骨转移,可用于分析。共有15例转移灶的SUV max降低;中位降幅为42%,最大降幅为82%。SUV max的绝对减少量随着预处理SUV max的增加而增加。一名患者在治疗后表现出增加的SUV max,这归因于骨转移背景下正常的肿瘤周围骨再生。在每个剂量水平下,非肿瘤骨的中位数减少15%-34%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer
Breast cancer commonly metastasises to the skeleton, and stereotactic ablative body radiation therapy (SABR) is an emerging treatment for oligometastatic disease. Accurately imaging bone metastases and their response to treatment is challenging. [ 18 F]NaF-PET has a higher sensitivity and specificity than conventional bone scans for detecting breast cancer bone metastases. In this pre-defined secondary analysis of a prospective trial, we evaluated the change in [ 18 F]NaF uptake after SABR. Patients with oligometastatic breast cancer received a single fraction of 20 Gy to up to three bone metastases. [ 18 F]NaF-PET was acquired before and 12 months after SABR. Pre- and post-treatment [ 18 F]NaF-PET images were registered to the treatment planning CT. The relative change in tumour SUV max and SUV mean was quantified. The intersection of each of the radiation therapy isodose contours with a non-tumour bone was created. The change in SUV mean in sub-volumes of non-tumour bone receiving doses of 0–20 Gy was quantified. In total, 14 patients, with 17 bone metastases, were available for analysis. A total of 15 metastases exhibited a reduction in SUV max ; the median reduction was 42% and the maximum reduction 82%. An increased absolute reduction in SUV max was observed with higher pre-treatment SUV max . One patient exhibited increased SUV max after treatment, which was attributed to normal peri-tumoural bone regeneration in the context of a bone metastasis. There was a median reduction of 15%–34% for non-tumour bone in each dose level.
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