用于sars-cov-2检测的电化学生物传感器

Maria S. Andrianova, Olga S. Panova, Alexey A. Titov, Natalia V. Komarova, Alexander E. Kuznetsov
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引用次数: 0

摘要

2019冠状病毒病(COVID-19)疫情已成为全球性疫情。这一流行病对社会经济的空前影响突出表明,有必要改进现有的诊断方法,并开发控制该疾病传播的新方法。自SARS-CoV-2基因组序列公布以来,定量实时聚合酶链反应(qRT-PCR)等传统技术一直被认为是检测新冠病毒的金标准。然而,它们是耗时的,劳动密集型的,并不能保证没有错误的结果。电化学生物传感器提出了检测病毒核酸或病毒抗原的替代方法。传感器和设备的高灵敏度、相对较低的成本、方便的管理、快速的分析以及适合小型化,可能有助于COVID-19即时检测(POC)的发展。本文对用于新型冠状病毒检测的现代电化学生物传感器及其相关技术进行了审查和批判性讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ELECTROCHEMICAL BIOSENSORS FOR SARS-COV-2 DETECTION
The 2019 coronavirus disease (COVID-19) outbreak has become global. The unprecedented socioeconomic impact of the pandemic has highlighted the need to improve existing diagnostic methods and develop new methods to control the spread of the disease. Traditional technologies such as quantitative real-time polymerase chain reaction (qRT-PCR) have been considered the gold standard for testing for COVID-19 since the SARS-CoV-2 genome sequence was published. However, they are time-consuming, labor-intensive and do not guarantee the absence of false results. Electrochemical biosensors present alternative approaches to detect viral nucleic acids or viral antigens. High sensitivity, relatively low cost of sensors and equipment, convenient management, rapid analysis, and suitability for miniaturization may contribute to the development of point-of-care (POC) testing for COVID-19. The review examines and critically discusses modern electrochemical biosensors for SARS-CoV-2 detection and related technologies.
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