杜匹单抗治疗特应性皮炎的长期疗效和安全性:一项单中心回顾性研究

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Michela Ortoncelli, Nicole Macagno, Luca Mastorino, Federica Gelato, Irene Richiardi, Giovanni Cavaliere, Pietro Quaglino, Simone Ribero
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引用次数: 0

摘要

dupilumab治疗特应性皮炎(AD)的长期有效性和安全性数据很少。这项研究的目的是评估dupilumab在治疗开始后长达三年的疗效和安全性。材料和方法:我们收集了2018年12月至2022年10月在都灵大学医院皮肤科诊所开始使用dupilumab的≥12岁严重AD患者的数据。临床和患者报告的结果从基线开始评估,直到3年(T9),每4个月评估一次。结果:共观察418例患者。平均easi逐渐下降:从基线时的23.64降至T9时的2.31。在患者报告的结果中也观察到类似的趋势。T1(4个月)时达到EASI75和EASI90的患者分别为75.58%和53.49%,T9时分别为92.55%和80.85%;DLQI 0/1在T9时达到61.7%。94例患者中有86例(91.5%)在T9时达到平均NRSpp≤4。最常见的不良事件是结膜炎,在每个分析时间点平均有13%的患者发生。结论:Dupilumab在临床实践中被证明是治疗AD的有效和安全的,可达3年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Efficacy and Safety of Dupilumab in Patients with Atopic Dermatitis: A Single-Centre Retrospective Study
Introduction: There are few long-term effectiveness and safety data for dupilumab in the treatment of atopic dermatitis (AD). The aim of this study was to evaluate efficacy and safety of dupilumab for up to three years after treatment initiation. Materials and Methods: We collected data from patients ≥ 12 years with severe AD who started dupilumab at the Dermatology Clinic of the Turin University Hospital between December 2018 and October 2022. Clinic and patient reported outcomes were evaluated from baseline, up to 3 years (T9), every 4 months. Results: A total of 418 patients were observed. A progressive decrease in the meanEASI was observed: from 23.64 at baseline to 2.31 at T9. Similar trends were observed in patients’ reported outcomes. The achievement of EASI75 and EASI90 was observed in 75.58% of patients and 53.49%, respectively, at T1 (4 months), and in 92.55% and 80.85% at T9; DLQI 0/1 was achieved at T9 in 61.7%. Mean NRSpp ≤ 4 was achieved at T9 in 91.5% (86 out of 94 patients). The most common adverse event was conjunctivitis occurring in 13% of patients on average at each timepoint analyzed. Conclusions: Dupilumab proved to be effective and safe for the treatment of AD in clinical practice, up to 3 years.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
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