软骨终板:全面回顾椎间盘研究中被忽视的结构

IF 3.4 3区 医学 Q1 ORTHOPEDICS
JOR Spine Pub Date : 2023-10-21 DOI:10.1002/jsp2.1294
Katherine B. Crump, Ahmad Alminnawi, Paola Bermudez-Lekerika, Roger Compte, Francesco Gualdi, Terence McSweeney, Estefano Muñoz-Moya, Andrea Nüesch, Liesbet Geris, Stefan Dudli, Jaro Karppinen, Jérôme Noailly, Christine Le Maitre, Benjamin Gantenbein
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引用次数: 0

摘要

软骨内板(CEP)是椎间盘(IVD)的关键组成部分,是维持椎间盘营养、分散机械负荷和防止椎间盘膨出到邻近椎体的必要条件。CEP 的大小、形状和成分对维持其功能至关重要,CEP 的退化被认为是导致 IVD 早期退化的一个因素。此外,CEP 还与 Modic 变化有关,而 Modic 变化通常与腰背痛有关。这篇综述旨在探讨目前关于CEP的知识,包括CEP的结构、组成、渗透性、在健康椎间盘中的机械作用、它们如何随着退变而变化,以及它们如何与IVD退变和腰背痛相关联。此外,作者还建议对 CEP 和骨性终板进行标准化命名,并建议避免使用椎体终板一词。目前,有关 CEP 本身的数据有限,因为报告的数据往往是 CEP 和骨性终板的组合,或者将 CEP 视为关节软骨。然而,CEP 显然是一种独特的组织类型,不同于关节软骨、骨终板和其他 IVD 组织。因此,未来的研究应单独研究CEP,以充分了解其在健康和退化的IVD中的作用。此外,尽管CEP在IVD的营养和机械稳定性方面起着关键作用,但大多数正在开发的IVD再生疗法都没有涉及或甚至没有考虑到CEP。因此,未来的可持续疗法应考虑并可能以CEP为目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD) necessary for sustaining the nutrition of the disc while distributing mechanical loads and preventing the disc from bulging into the adjacent vertebral body. The size, shape, and composition of the CEP are essential in maintaining its function, and degeneration of the CEP is considered a contributor to early IVD degeneration. In addition, the CEP is implicated in Modic changes, which are often associated with low back pain. This review aims to tackle the current knowledge of the CEP regarding its structure, composition, permeability, and mechanical role in a healthy disc, how they change with degeneration, and how they connect to IVD degeneration and low back pain. Additionally, the authors suggest a standardized naming convention regarding the CEP and bony endplate and suggest avoiding the term vertebral endplate. Currently, there is limited data on the CEP itself as reported data is often a combination of CEP and bony endplate, or the CEP is considered as articular cartilage. However, it is clear the CEP is a unique tissue type that differs from articular cartilage, bony endplate, and other IVD tissues. Thus, future research should investigate the CEP separately to fully understand its role in healthy and degenerated IVDs. Further, most IVD regeneration therapies in development failed to address, or even considered the CEP, despite its key role in nutrition and mechanical stability within the IVD. Thus, the CEP should be considered and potentially targeted for future sustainable treatments.

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来源期刊
JOR Spine
JOR Spine ORTHOPEDICS-
CiteScore
6.40
自引率
18.90%
发文量
42
审稿时长
10 weeks
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