{"title":"疟原虫感染对CD4细胞、中性粒细胞和淋巴细胞的影响","authors":"Emmanuel Chike Amadi, Chukwuemeka Chijoke Nwangwu, Emmanuel A. Eze, Sylvia Ijeoma Adaugo Anyaehie","doi":"10.56397/ist.2023.11.03","DOIUrl":null,"url":null,"abstract":"Knowledge of malaria-immunity is essential for understanding the pathology, treatment & vaccine production. So, changes in CD4 in malaria patients were studied at a teaching hospital in Enugu, Nigeria. 45 patients on doctor’s provisional diagnosis of malaria were examined for Plasmodium infections and the degree of parasitaemia (0/+/ ++/ & +++). Positive/(+) and negative/(0) samples were thereafter counted for CD4 using Flow Cytometry. CD4 cell count of Plasmodium-negative specimens were within reference ranges (RR): (464-1308); mean value: 835. Fifteen (+) parasitaemia showed lower ranges of CD4 count (502-1282); mean: 678; with immune falls in one (427). 9/12 (++) parasitaemia showed crash in CD4 counts, range: 301- 415; mean: 399. Seven (+++) parasitaemia showed crashes in CD4 counts, range: 160-357; mean: 225. As parasitaemia rises, neutrophils, Total WBC and lymphocyte significantly rise in numeric. Malaria causes immunosuppression; unlike prevailing reports, should accelerate complications in immunodeficients-patients, Haemolytic-anaemia results only from chronic cases. CD4 counts should be a paradigm in malaria investigation.","PeriodicalId":20688,"journal":{"name":"Proceedings of The 6th International Conference on Innovation in Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Plasmodium Infections on CD4 Cells, Neutrophil and Lymphocytes\",\"authors\":\"Emmanuel Chike Amadi, Chukwuemeka Chijoke Nwangwu, Emmanuel A. Eze, Sylvia Ijeoma Adaugo Anyaehie\",\"doi\":\"10.56397/ist.2023.11.03\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Knowledge of malaria-immunity is essential for understanding the pathology, treatment & vaccine production. So, changes in CD4 in malaria patients were studied at a teaching hospital in Enugu, Nigeria. 45 patients on doctor’s provisional diagnosis of malaria were examined for Plasmodium infections and the degree of parasitaemia (0/+/ ++/ & +++). Positive/(+) and negative/(0) samples were thereafter counted for CD4 using Flow Cytometry. CD4 cell count of Plasmodium-negative specimens were within reference ranges (RR): (464-1308); mean value: 835. Fifteen (+) parasitaemia showed lower ranges of CD4 count (502-1282); mean: 678; with immune falls in one (427). 9/12 (++) parasitaemia showed crash in CD4 counts, range: 301- 415; mean: 399. Seven (+++) parasitaemia showed crashes in CD4 counts, range: 160-357; mean: 225. As parasitaemia rises, neutrophils, Total WBC and lymphocyte significantly rise in numeric. Malaria causes immunosuppression; unlike prevailing reports, should accelerate complications in immunodeficients-patients, Haemolytic-anaemia results only from chronic cases. CD4 counts should be a paradigm in malaria investigation.\",\"PeriodicalId\":20688,\"journal\":{\"name\":\"Proceedings of The 6th International Conference on Innovation in Science and Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of The 6th International Conference on Innovation in Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56397/ist.2023.11.03\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of The 6th International Conference on Innovation in Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56397/ist.2023.11.03","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Plasmodium Infections on CD4 Cells, Neutrophil and Lymphocytes
Knowledge of malaria-immunity is essential for understanding the pathology, treatment & vaccine production. So, changes in CD4 in malaria patients were studied at a teaching hospital in Enugu, Nigeria. 45 patients on doctor’s provisional diagnosis of malaria were examined for Plasmodium infections and the degree of parasitaemia (0/+/ ++/ & +++). Positive/(+) and negative/(0) samples were thereafter counted for CD4 using Flow Cytometry. CD4 cell count of Plasmodium-negative specimens were within reference ranges (RR): (464-1308); mean value: 835. Fifteen (+) parasitaemia showed lower ranges of CD4 count (502-1282); mean: 678; with immune falls in one (427). 9/12 (++) parasitaemia showed crash in CD4 counts, range: 301- 415; mean: 399. Seven (+++) parasitaemia showed crashes in CD4 counts, range: 160-357; mean: 225. As parasitaemia rises, neutrophils, Total WBC and lymphocyte significantly rise in numeric. Malaria causes immunosuppression; unlike prevailing reports, should accelerate complications in immunodeficients-patients, Haemolytic-anaemia results only from chronic cases. CD4 counts should be a paradigm in malaria investigation.
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